Acute MRI in Transient Ischemic Attack

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2014 by Bispebjerg Hospital
Sponsor:
Information provided by (Responsible Party):
Hanne Christensen, Bispebjerg Hospital
ClinicalTrials.gov Identifier:
NCT01531946
First received: February 9, 2012
Last updated: July 15, 2014
Last verified: July 2014
  Purpose

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of Arterial spin labeling (ASL) perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate diagnosis.


Condition Intervention
Ischemic Attack, Transient
Procedure: MRI Scan

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Acute MRI-techniques for the Detection of Ischemic Lesions After Transient Ischemic Attack

Resource links provided by NLM:


Further study details as provided by Bispebjerg Hospital:

Primary Outcome Measures:
  • frequency of patients with ischaemic lessions on DTI [ Time Frame: on first MRI ] [ Designated as safety issue: No ]
    We want to assess the frequency of patients in whom a diffusion restricted lesion can only be observed on DTI


Estimated Enrollment: 300
Study Start Date: January 2012
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: MRI Scan

    Patients will have to spend additional 10min in the scanner.

    Additional scan modalities used:

    1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia.
    2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions.

    An overall 20min scan period.

Detailed Description:

The purpose of this study is to detect acute ischemic lesions in patients admitted with symptoms of transient ischemic attack (TIA).

Diffusion weighted Imaging (DWI) is today one of the best ways to detect ischemic lesions after TIA. The problem is that this only gives the diagnosis in 30% of the cases.

It is possible that the addition of ASL-perfusion imaging and diffusion tensor imaging will make it possible to give a more accurate and selective diagnosis of TIA.

Patients admitted with clinical signs of TIA can be included. Patients will be examined with the TIA protocol in reference to the standardized clinical care:

  1. 1,5 tesla gradient echo and 3 tesla Susceptibility weighted imaging (SWI) to detect microbleed as sign of small vessel disease.
  2. Axial T2 FLAIR to detect white matter lesions.
  3. Axial DWI to detect areas with impeded diffusion.

(Total scantime 10min)

If no signs of ischemic lesions is detected the following additional research scan-protocol will be initiated:

  1. Perfusion without contrast: Arterial spin labeling (ASL) with the ability of showing signs of ischemia.
  2. Diffusion tensor imaging (DTI): Has a higher sensitivity than DWI in displaying local ischemic lesions.

(Total additional scantime 10min)

All in All 20min in the scanner.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients admitted to the stroke ward at Bispebjerg University Hospital with signs of TIA.

Criteria

Inclusion Criteria:

  • Clinical signs of TIA
  • Informed consent
  • No serious respiratory or cardiac implications

Exclusion Criteria:

  • Contraindications to MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01531946

Contacts
Contact: Hanne Christensen, MD, DMSci hchr0039@bbh.regionh.dk
Contact: Anders Christensen, MD, Ph.D

Locations
Denmark
Bispebjerg Hospital Recruiting
Copenhagen, Capital Region, Denmark, DK-2400
Contact: Hanne Christensen, MD, DMSci       hchr0039@bbh.regionh.dk   
Sponsors and Collaborators
Bispebjerg Hospital
Investigators
Principal Investigator: Hanne Christensen, MD, DMSci Department of Neurology and Cerebrovascular Diseases, Bispebjerg Hospital
  More Information

Publications:
Responsible Party: Hanne Christensen, Associate Research Professor, Consultant Neurologist, Bispebjerg Hospital
ClinicalTrials.gov Identifier: NCT01531946     History of Changes
Other Study ID Numbers: H-1-2011-75
Study First Received: February 9, 2012
Last Updated: July 15, 2014
Health Authority: Denmark: National Board of Health

Keywords provided by Bispebjerg Hospital:
Diffusion Tensor Imaging

Additional relevant MeSH terms:
Ischemia
Ischemic Attack, Transient
Pathologic Processes
Brain Ischemia
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on October 19, 2014