Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress
The objective of this randomized, double-blind, placebo-controlled, parallel-design clinical trial is to investigate the potential antioxidant benefits of a cranberry beverage. The investigators hypothesize the chronic consumption of this beverage will improve indices of oxidative stress, inflammation, endothelial function, and glucoregulation. The investigators also hypothesize that these benefits will be particularly evident following an oral glucose tolerance test.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
|Official Title:||The Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress in Healthy But Overweight/Obese Subjects: A Randomized Clinical Trial|
- Change in biomarkers of inflammation compared with placebo [ Time Frame: Baseline and 8 weeks ] [ Designated as safety issue: No ]
- Change in biomarkers of oxidative stress compared with placebo. [ Time Frame: Baseline and 8 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||February 2012|
|Study Completion Date:||February 2013|
|Primary Completion Date:||January 2013 (Final data collection date for primary outcome measure)|
|Active Comparator: Cranberry beverage||
beverage containing cranberry at a dose of 15.2 ounces per day for 56 days.
|Placebo Comparator: Non-cranberry beverage||
Other: Non-Cranberry beverage
Placebo Comparator - beverage absent cranberry at a dose of 15.2 ounces per day for 56 days.
|United States, Massachusetts|
|Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University|
|Boston, Massachusetts, United States, 02111|
|United States, Washington|
|Washington State University|
|Pullman, Washington, United States, 99164|