Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Ain Shams Maternity Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
nermin marzouk agaibi, Ain Shams Maternity Hospital
ClinicalTrials.gov Identifier:
NCT01523327
First received: January 30, 2012
Last updated: January 31, 2012
Last verified: January 2012
  Purpose

Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.


Condition Intervention
Uric Acid and Hypertension in Pregnancy
Other: measuring protein creatinin ratio,serum uric acid

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension

Resource links provided by NLM:


Further study details as provided by Ain Shams Maternity Hospital:

Estimated Enrollment: 80
Study Start Date: October 2011
Estimated Study Completion Date: October 2012
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
A
40 pregnant Women with hypertension who have uric acid level more than 6 mg per dL.
Other: measuring protein creatinin ratio,serum uric acid

A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate.

Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.

B
40 pregnant women with hypertension who have uric acid level less than 6 mg per dl.
Other: measuring protein creatinin ratio,serum uric acid

A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate.

Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.


Detailed Description:

Association of maternal uric acid with maternal condition(renal function,liver function,...ect.) and fetal outcome(birth weight,APGER score) in pregnant women with hypertension.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

The study will include 80 pregnant ladies with hypertension admitted to the maternity ward of the hospital who will be divided into two groups according to their uric acid level.

Criteria

Inclusion Criteria:

  • Age:18-40 years old
  • Gestational age:28-42 weeks gestation singleton pregnancy of living fetus
  • Non smoker

Exclusion Criteria:

  • women who refuse the study
  • Any medical or obstetric disorders especially D.M.,renal disease,hepatic, cardiac disorders or gout arthritis, other than hypertension if present.
  • Previously elevated uric acid level.
  • Hemolytic or sickle cell anemia,urinary tract infection.
  • Use of diuretics or anti-inflammatory drugs.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01523327

Contacts
Contact: Nermin marzouk touma, M.B.,B.Ch 01222740182 ext 002 nermindave@gmail.com
Contact: nermin Marzouk touma, M.B.,B.Ch 0862636607 ext 002 nermindave@gmail.com

Locations
Egypt
Ain shams maternity hospital Recruiting
Cairo, Egypt, 11117
Principal Investigator: nermin marzouk touma, M.B.,B.Ch         
Sponsors and Collaborators
Ain Shams Maternity Hospital
Investigators
Study Director: Mohamed Saeedeldin Elsafty, assistant lecture Ain Shams Maternity Hospital
  More Information

Additional Information:
Publications:
Responsible Party: nermin marzouk agaibi, Nermin Marzouk Agaibi, Ain Shams Maternity Hospital
ClinicalTrials.gov Identifier: NCT01523327     History of Changes
Other Study ID Numbers: ainshamsMH
Study First Received: January 30, 2012
Last Updated: January 31, 2012
Health Authority: Egypt: Ministry of Health and Population

Keywords provided by Ain Shams Maternity Hospital:
Uric acid

Additional relevant MeSH terms:
Hypertension
Hypertension, Pregnancy-Induced
Pre-Eclampsia
Vascular Diseases
Cardiovascular Diseases
Pregnancy Complications
Uric Acid
Antioxidants
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protective Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on July 26, 2014