Effect of the Salbutamol on Mechanical Properties of Respiratory System
Recruitment status was Recruiting
The aim of this study is to assess the bronchodilator response of salbutamol on respiratory mechanics of healthy individuals, smokers and COPD with varying degrees of airway obstruction.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Effect of the Use of Salbutamol on the Mechanical Properties of the Respiratory System of Healthy Individuals, Smokers and COPD Patients|
- Respiratory function test [ Time Frame: two o'clock ] [ Designated as safety issue: No ]Evaluation of pulmonary mechanics before and after salbutamol (short-acting bronchodilator) in healthy individuals, smokers and chronic obstructive pulmonary disease in stages: mild, moderate, severe and very severe according to GOLD criteria.
- Salbutamol [ Time Frame: twenty minutes ] [ Designated as safety issue: Yes ]In the bronchodilator test will be used 400 micrograms of beta2-agonist short-acting. They will be asked to exhale slowly until they can no longer expel more air from the lungs. To place the inhaler with a spacer between the lips, pressing them well, but no bite. Shortly thereafter start to breathe through the mouth and will be released a jet of 100 micrograms of the bronchodilator. Then they will hold their breath for 10 seconds. 3 puffs are made with 1 minute interval between each application.
|Study Start Date:||June 2011|
|Estimated Study Completion Date:||September 2012|
|Estimated Primary Completion Date:||January 2012 (Final data collection date for primary outcome measure)|
Short-acting bronchodilator for use in humans released by the Ministry of Health, widely used worldwide for the treatment of chronic obstructive pulmonary disease.
Drug: Salbutamol sulphate
bronchodilator test, beta2-agonist, short-acting, six hours duration, 400 micrograms.
Clinical evaluation will be conducted and anthropometric measurements, then the pulmonary function tests: forced oscillation technique (FOT), whole body plethysmography, spirometry and-administration of salbutamol aerosol for assessment of bronchodilator response. After 20 minutes, the individual will be evaluated again following the same sequence.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01521572
|Contact: Agnaldo J Lopes, PhD||55+(21) firstname.lastname@example.org|
|Contact: Pedro L de Melo, PhD||55+(21) email@example.com|
|Laboratory biomedical instrumentation - State University of Rio de Janeiro||Recruiting|
|Rio de Janeiro, Brazil, 20550013|
|Principal Investigator: Gerusa M Costa, MSc|
|Principal Investigator:||Gerusa M Costa, MSc||State University of Rio de Janeiro|
|Study Director:||Pedro L Melo, PhD||Laboratory biomedical instrumentation|