How Fat Influences the Brain

This study has been completed.
Sponsor:
Collaborators:
German Research Foundation
AiF
Zentrum für Ernährungsmedizin
German Center for Diabetes Research (DZD e.V.)
University of Hohenheim
Information provided by (Responsible Party):
Sabine Frank, University Hospital Tuebingen
ClinicalTrials.gov Identifier:
NCT01516021
First received: January 9, 2012
Last updated: January 18, 2012
Last verified: January 2012
  Purpose

The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.


Condition Intervention
Fat Processing in the Brain
Dietary Supplement: intake of high or low fat yoghurt

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Fat Intake Modulates Cerebral Blood Flow in Homeostatic and Gustatory Brain Areas in Humans

Further study details as provided by University Hospital Tuebingen:

Primary Outcome Measures:
  • Changes in Cerebral Blood Flow due to the high or low fat yoghurt intake after 30 minutes and 120 minutes compared to a baseline measurement 30 minutes before yoghurt intake. [ Time Frame: 30 minutes before as well as 30 minutes and 120 minutes after fat intake ] [ Designated as safety issue: No ]

    We were interested in differential brain activations due to the high or low fat meal. To assess this, the mentioned time points are suitable.

    The Cerebral Blood Flow is measured using Arterial Spin Labeling sequences in a functional magnetic resonance tomography.



Enrollment: 11
Study Start Date: January 2011
Study Completion Date: March 2011
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: high fat yoghurt intake
500 ml of a high fat yoghurt
Dietary Supplement: intake of high or low fat yoghurt
intake of 500 ml of a high fat yoghurt on one day and intake of 500 ml of a low fat yoghurt on the other day
Experimental: low fat yoghurt intake Dietary Supplement: intake of high or low fat yoghurt
intake of 500 ml of a high fat yoghurt on one day and intake of 500 ml of a low fat yoghurt on the other day

  Eligibility

Ages Eligible for Study:   25 Years to 32 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male
  • healthy

Exclusion Criteria:

  • lactose intolerance
  • fMRI contraindications (metal implants,...)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01516021

Locations
Germany
University Clinic of Tuebingen, MEG Center
Tuebingen, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen
German Research Foundation
AiF
Zentrum für Ernährungsmedizin
German Center for Diabetes Research (DZD e.V.)
University of Hohenheim
  More Information

No publications provided by University Hospital Tuebingen

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Sabine Frank, Principal Investigator, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT01516021     History of Changes
Other Study ID Numbers: YOG
Study First Received: January 9, 2012
Last Updated: January 18, 2012
Health Authority: Germany: Ethics Commission

Keywords provided by University Hospital Tuebingen:
Fat ingestion
hypothalamus
insula
fMRI
CBF

ClinicalTrials.gov processed this record on April 17, 2014