LOXL1 Polymorphism in Pseudoexfoliation Syndrome

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Samsung Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT01515735
First received: January 18, 2012
Last updated: January 23, 2012
Last verified: January 2012
  Purpose

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.


Condition
Pseudoexfoliation Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Evaluation of LOXL1 Polymorphism in Pseudoexfoliation Syndrome in the Korean Population

Resource links provided by NLM:


Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, rs2165241) [ Time Frame: about 1 year (when all patients were recruited) ] [ Designated as safety issue: Yes ]
    Genotypes of the three single nucleotide polymorphisms of LOXL1 were analyzed by direct sequencing, after obtained from the peripheral blood sampling from patients.


Biospecimen Retention:   Samples With DNA

Peripheral blood sample


Estimated Enrollment: 60
Study Start Date: December 2011
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
pseudoexfoliation
The study group composted of the patients with pseudoexfoliation syndrome

Detailed Description:

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.

And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

  Eligibility

Ages Eligible for Study:   20 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

the groups or cohorts will be recruited from glaucoma clinic in Samsung medical center

Criteria

Inclusion Criteria:

  • Clinical diagnosis of Pseudoexfoliation

Exclusion Criteria:

  • medical condition that peripheral blood sampling cannot be done
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01515735

Contacts
Contact: Changwon Kee, M.D., Ph.D. 82-2-3410-3564 ckee@skku.edu

Locations
Korea, Republic of
Samsung medical center Recruiting
Seoul, Korea, Republic of, 135710
Contact: Changwon Kee, M.D., Ph.D    82-2-3410-3564    ckee@skku.edu   
Principal Investigator: changwon Kee, M.D., Ph.D         
Sponsors and Collaborators
Samsung Medical Center
Investigators
Study Chair: Changwon Kee, M.D., PhD Samsung Medical Center
  More Information

Publications:
Responsible Party: Samsung Medical Center
ClinicalTrials.gov Identifier: NCT01515735     History of Changes
Other Study ID Numbers: 2011-06-035
Study First Received: January 18, 2012
Last Updated: January 23, 2012
Health Authority: South Korea: Institutional Review Board

Additional relevant MeSH terms:
Exfoliation Syndrome
Iris Diseases
Uveal Diseases
Eye Diseases

ClinicalTrials.gov processed this record on July 20, 2014