Brain-imaging and Adolescent Neuroscience Consortium (BANC)
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Brain-imaging and Adolescent Neuroscience Consortium|
Saliva DNA samples for future analyses.
|Study Start Date:||September 2012|
|Estimated Study Completion Date:||September 2017|
|Estimated Primary Completion Date:||March 2017 (Final data collection date for primary outcome measure)|
A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).
A sample of adolescents who have a >1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan
High risk sample
High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.
|United States, Massachusetts|
|Belmont, Massachusetts, United States, 02478|
|Massachusetts General Hospital|
|Boston, Massachusetts, United States, 02114|
|Boston University School of Medicine|
|Boston, Massachusetts, United States, 02118|
|Massachusetts Institute of Technology|
|Cambridge, Massachusetts, United States, 02139|
|Principal Investigator:||John R Knight, MD||Children's Hospital Boston|
|Principal Investigator:||Gordon J Harris, PhD||Massachusetts General Hospital|
|Principal Investigator:||Simon Warfield, PhD||Children's Hospital Boston|
|Principal Investigator:||Avram Holmes, PhD||Harvard University|
|Principal Investigator:||Scott Lukas, PhD||Mclean Hospital|
|Principal Investigator:||Marisa Silveri, PhD||Mclean Hospital|
|Principal Investigator:||Marlene Oscar Berman, PhD||Boston University|
|Principal Investigator:||John Gabrieli, PhD||Massachusetts Institute of Technology|