Brain-imaging and Adolescent Neuroscience Consortium (BANC)
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Purpose
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.
| Condition |
|---|
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Alcohol Abuse |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Brain-imaging and Adolescent Neuroscience Consortium |
Saliva DNA samples for future analyses.
| Enrollment: | 0 |
| Study Start Date: | September 2012 |
| Estimated Study Completion Date: | September 2017 |
| Estimated Primary Completion Date: | March 2017 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Alcohol-naive adolescents
A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).
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Treatment sample
A sample of adolescents who have a >1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan
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High risk sample
High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)
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Detailed Description:
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.
Eligibility| Ages Eligible for Study: | 12 Years to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Male and female adolescents 12-21 years-of-age presenting for care at one of the participating medical clinics
Inclusion Criteria:
- able to read and understand English
- available for follow-up
- parental consent/adolescent assent for those 12-17 years
- consent for those 18-21 years
Exclusion Criteria:
- Weight > 300 lbs
- braces or unremovable embedded metal
- claustrophobia or inability to lie still in MRI machine
- current or past 12-mos pregnancy (females)
- requires urgent medical/mental health care
Contacts and Locations| United States, Massachusetts | |
| McLean Hospital | |
| Belmont, Massachusetts, United States, 02478 | |
| Massachusetts General Hospital | |
| Boston, Massachusetts, United States, 02114 | |
| Boston University School of Medicine | |
| Boston, Massachusetts, United States, 02118 | |
| Massachusetts Institute of Technology | |
| Cambridge, Massachusetts, United States, 02139 | |
| Principal Investigator: | John R Knight, MD | Children's Hospital Boston |
| Principal Investigator: | Gordon J Harris, PhD | Massachusetts General Hospital |
| Principal Investigator: | Simon Warfield, PhD | Children's Hospital Boston |
| Principal Investigator: | Avram Holmes, PhD | Harvard University |
| Principal Investigator: | Scott Lukas, PhD | Mclean Hospital |
| Principal Investigator: | Marisa Silveri, PhD | Mclean Hospital |
| Principal Investigator: | Marlene Oscar Berman, PhD | Boston University |
| Principal Investigator: | John Gabrieli, PhD | Massachusetts Institute of Technology |
More Information
Additional Information:
No publications provided
| Responsible Party: | Children's Hospital Boston |
| ClinicalTrials.gov Identifier: | NCT01511679 History of Changes |
| Other Study ID Numbers: | BANC RFA-AA-12-006 |
| Study First Received: | January 13, 2012 |
| Last Updated: | January 2, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Children's Hospital Boston:
|
Alcohol abuse |
Additional relevant MeSH terms:
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Alcoholism Alcohol-Related Disorders Substance-Related Disorders Mental Disorders |
ClinicalTrials.gov processed this record on June 17, 2013