Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2011 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT01503723
First received: January 2, 2012
Last updated: January 3, 2012
Last verified: September 2011
  Purpose

Metabolomics, or metabonomics, is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Metabolomics allows for a global assessment of a cellular state within the context of the immediate environment, taking into account genetic regulation, altered kinetic activity of enzymes, and changes in metabolic reactions. Metabolomics may be useful for understanding metabolic imbalances and for diagnosis of human disease. The investigators plan to collect exhaled breath condensate from patients with acute lung injury. Metabolomic analysis in the patients may help us to explore some novel biomarkers for the disease diagnosis and outcome prediction.


Condition Intervention
Acute Lung Injury
Other: Determined by intended physician

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • Diagnosis [ Time Frame: 28 days ] [ Designated as safety issue: No ]
    To differentiate ALI/ARDS from cardiogenic pulmonary edema or other causes

  • Disease severity [ Time Frame: 28 days ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Exhaled breath condensate


Estimated Enrollment: 300
Study Start Date: August 2011
Groups/Cohorts Assigned Interventions
Patients with acute lung injury
Patients who are admitted to ICU with the diagnosis of acute hypoxemic respiratory failure
Other: Determined by intended physician
We perform a prospective observational study. All the treatment for the patients are determined by intended physicians.

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients who are admitted to ICU with the diagnosis of acute hypoxemic respiratory failure and endotracheally intubated with mechanical ventilation.

Criteria

Inclusion Criteria:

  • above 18 years old
  • admitted to ICU with the diagnosis of acute hypoxemic respiratory failure and endotracheally intubated with mechanical ventilation.

Exclusion Criteria:

  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01503723

Contacts
Contact: Lu-Cheng Kuo, MD, Master 886-2-23562905 kuolc@ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Lu-Cheng Kuo, MD, Master    886-2-23562905    kuolc@ntu.edu.tw   
Principal Investigator: Lu-Cheng Kuo, MD, Master         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Lu-Cheng Kuo, MD, Master National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01503723     History of Changes
Other Study ID Numbers: 201103016RC
Study First Received: January 2, 2012
Last Updated: January 3, 2012
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Lung Injury
Wounds and Injuries
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Thoracic Injuries

ClinicalTrials.gov processed this record on August 26, 2014