The Effect of Vitamin D Supplementation on Arterial Stiffness in Diabetic Patients
The incidence of type 2 Diabetes Mellitus is increasing at an alarming rate worldwide.
Cardiovascular disease is the leading cause of death in patients with type 2 diabetes.
Recently, increasing amount of evidence suggests that vitamin D may influence various nonskeletal medical conditions, including cardiovascular disease, hypertension, diabetes, cancer, autoimmune disorders and more. The purpose of this trial is to investigate the effect of vitamin D supplementation on 24 hours blood pressure monitoring, arterial stiffness, oxidative stress and inflammation in vitamin D deficient diabetic patients.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
|Official Title:||The Effect of Vitamin D Supplementation on Arterial Stiffness, Blood Pressure, Oxidative Stress and Inflammation in Diabetic Patients|
- arterial stiffness [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- blood pressure holter [ Time Frame: 3 months ] [ Designated as safety issue: No ]
|Study Start Date:||August 2010|
|Study Completion Date:||April 2011|
|Primary Completion Date:||January 2011 (Final data collection date for primary outcome measure)|
Experimental: vitamin D
Baby D3 drops
Drug: Baby D3 drops
2000-4000 iu per day
Other Name: vitamin D
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|Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel|
|Zerifin, Israel, 70300|
|Principal Investigator:||Shlomit koren, MD||Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel|