Nottingham Osteoarthritis Biomarker Study 2011
Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers.
This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Nottingham Osteoarthritis Biomarker Study 2011|
- Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees. [ Time Frame: within 6 months of recruitment of last participant ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Serum, urine and synovial fluid.
|Study Start Date:||February 2012|
|Study Completion Date:||January 2013|
|Primary Completion Date:||January 2013 (Final data collection date for primary outcome measure)|
|No knee pain/osteoarthritis|
|Academic Rheumatology, University of Nottingham|
|Nottingham, United Kingdom, NG5 1PB|
|Principal Investigator:||Michael Doherty, MA MB FRCP||University of Nottingham|