Study of Cholesterol Levels and Types in African Americans With Type 2 Diabetes (LAAD)
Compared to other races, African-Americans with type 2 diabetes have different cholesterol levels, specifically triglycerides and low density lipoprotein. Recent data has shown the not only are cholesterol levels important in determining the risk for cardiovascular disease, but the size of the cholesterol particles and surface proteins on the cholesterol particles are also important. The objective of this study is to determine if African-American males with diabetes have different particle size, surface proteins, and cholesterol genetic links than African-American male without diabetes and Caucasian-American males with and without diabetes.
African-American males with type 2 diabetes and not taking lipid-lowering medications are the current target population. The results of their lab analysis will be compared to results from a previous study conducted by Dr. Momary, a co-investigator,that included African-American men without diabetes and Caucasian men with and without diabetes.
After obtaining an informed consent, a complete medical history will be obtained and subjects will be examined, noninvasively, for physical signs of elevated cholesterol levels. Afterwards, blood samples [one venous puncture, 6 tubes (21 mL total)] will be obtained. Blood samples will be coded, sent to Berkeley Heart Lab and/or Clinical Laboratory Services, and undergo genetic testing at Mercer University College of Pharmacy and Health Sciences.
Confidentiality of the subjects will be explained in the consenting process to the subjects. All subject samples and information will be coded. Each subject will be given a subject number upon consenting and this will be used throughout the study. All pertinent information of the subjects will be listed under the designated number, but will not be associated with that patient.
Type 2 Diabetes
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Preliminary Analysis of Lipoprotein Subclasses, Apoprotein Levels, and Genetic Architecture of African-American Males With Type 2 Diabetes. Lipids in African Americans With Type 2 Diabetes|
- Differences in lipoprotein a [Lp(a)] in African American males with diabetes and those without diabetes
- Differences in nonHDL levels in African American males with diabetes and those without diabetes
Biospecimen Retention: Samples With DNA
We will retain a sample of serum, plasma and whole blood.
|African American males with type 2 diabetes|
|United States, Georgia|
|Mercer Univeristy College of Pharmacy and Health Sciences||Recruiting|
|Atlanta, Georgia, United States, 30341|
|Contact: Gina J Ryan, PharmD 678-547-6222 email@example.com|
|Principal Investigator: Gina Ryan, PharmD|
|Grady Health System||Recruiting|
|Atlanta, Georgia, United States, 30303|
|Contact: Gina J Ryan, PharmD 404-616-3749 firstname.lastname@example.org|
|Principal Investigator: Gina J Ryan, PharmD|