Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since current information is lacking on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF), it will be investigated whether a regulation of these proteins could be an underlying cause of the disease. Mitochondrial function will also studied.
- The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
- The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation|
- structure of sarcolemma [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Myocardial tissue from the right and left atrial appendage.
|Study Start Date:||April 2010|
|Study Completion Date:||July 2012|
|Primary Completion Date:||February 2012 (Final data collection date for primary outcome measure)|
|stable sinus rhythm|
|permanent atrial fibrillation|
|paroxysmal atrial fibrillation|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01493128
|Study Director:||Ulrik Wisløff, PhD||Norwegian University of Science and Technology|