Neurocognitive Study for the Aging (NEUROAGE)

This study is currently recruiting participants.
Verified November 2011 by University of Cyprus
Sponsor:
Information provided by (Responsible Party):
Fofi Constantinidou, University of Cyprus
ClinicalTrials.gov Identifier:
NCT01481246
First received: November 25, 2011
Last updated: November 28, 2011
Last verified: November 2011
  Purpose

The Neurocognitive Study for the Aging (NEUROAGE) is funded by the Cyprus Research Promotion Foundation. The project focuses on the understanding of the effects of age on neurocognitive abilities such as attention, memory, language, categorization, and executive functioning. In addition, it will investigate the effects of a theory-driven hierarchical training program, the Categorization Program, to improve cognitive abilities in adults with Mild Cognitive Impairment (MCI). Over 500 adults over 65 years of age will participate in the project. The grant was awarded to the University of Cyprus. Partners include the Cyprus Institute of Neurology and Genetics and the Municipality of Strovolos (Multidynamic Research Center).


Condition Intervention
Aging
Memory Impairment
Cognitive Decline
Mild Cognitive Disorder
Behavioral: Categorization training

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Neurocognitive Study for the Aging

Resource links provided by NLM:


Further study details as provided by University of Cyprus:

Biospecimen Retention:   Samples With DNA

APOE phenotyping


Estimated Enrollment: 400
Study Start Date: July 2009
Estimated Study Completion Date: October 2014
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Normal Aging/Cognitive Decline Behavioral: Categorization training
Behavioral intervention consisting of cognitive training exercises to improve categorization performance
Other Name: Categorization Training

Detailed Description:

Given the fact that older adults are expected to live longer while maintaining their social and professional activities, the development of effective cognitive retraining methodologies designed to maximize independence has been of interest. In addition to changes caused by the normal aging process, older adults over 70 are at a high risk for developing dementia. About 8-12% of the older adult population will demonstrate a pre-dementia syndrome referred to as Mild Cognitive Impairment (MCI) which is considered the prodrome to dementia. Consequently, it is important to identify variables that contribute to the development of MCI as well as neurocognitive therapy approaches to help patients improve their level of functioning.

Categorization is one of the most fundamental cognitive processes. The ability to divide the world into discrete categories is a rudimentary process beginning early in life and continues to be developed and refined across the lifespan. (ref.1,2,10) This underlying process is crucial to a variety of neurocognitive abilities including attention and memory and can influence vocational and educational reintegration. Normal aging results in categorization deficits which in turn can interfere with the individual's ability to attend, remember, and organize information. This difficulty could hamper activities of daily living, social participation, and independence. This project implements an innovative treatment program based on current theoretical models of human cognition designed to improve neurocognitive abilities.

The primary objective of this project is to provide evidence on the effectiveness of a systematic and hierarchical neurocognitive therapy method, the Categorization Program (CP) in adults with MCI and in normal older adults. It is hypothesized that the CP will be an effective treatment approach to improve categorization abilities in both groups of subjects.

The following activities will take place:

  1. First, a population-based sample of 500 older adults will be tested using a battery of neuropsychological measures. Normal older adults will be reassessed in two years; individuals with indication for MCI will be assessed further to determine the presence of MCI.
  2. Second, normal OA and adults with MCI will be randomly assigned into either the treated or untreated groups. The treated groups will receive the CP training in order to test its effectiveness.
  3. Third, the long term effects of cognitive retraining up to 1 year post treatment will be assessed.
  4. Finally, the project will examine the relationship between the categorization tasks, neuropsychological performance, functional outcome measures, and subject characteristics including health indices, education, and biomarkers.

The long-term objective of this research program is to determine variables that influence cognitive decline in older adults and develop effective neurocognitive therapy techniques.

  Eligibility

Ages Eligible for Study:   60 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Normal older adults and adults with cognitive decline are recruited in this study

Criteria

Inclusion Criteria:

  • healthy with no prior neurological history

Exclusion Criteria:

  • prior neurological history diagnosis of AD, significant psychiatric history
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01481246

Contacts
Contact: Fofi Constantinidou, Ph.D. 35722892078 fofic@ucy.ac.cy

Locations
Cyprus
University of Cyprus Recruiting
Nicosia, Cyprus, 1678
Contact: Fofi Constantinidou, Ph.D.    35722894437    fofic@ucy.ac.cy   
Principal Investigator: Fofi Constantinidou, Ph.D.         
Sponsors and Collaborators
University of Cyprus
  More Information

Additional Information:
No publications provided

Responsible Party: Fofi Constantinidou, Professor, University of Cyprus
ClinicalTrials.gov Identifier: NCT01481246     History of Changes
Other Study ID Numbers: ΑΝΘΡΩ/ΚΟΙΝΩ/0308(ΒΕ)/07, ΑΝΘΡΩ/ΚΟΙΝΩ/0308(ΒΕ)/07
Study First Received: November 25, 2011
Last Updated: November 28, 2011
Health Authority: Cyprus: Research Promotion Foundation

Keywords provided by University of Cyprus:
neurorehabilitation
cognition
aging
MCI
cognitive decline

Additional relevant MeSH terms:
Cognition Disorders
Memory Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on April 17, 2014