Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of Subcutaneous MCAF5352A in Healthy Volunteers

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Genentech
ClinicalTrials.gov Identifier:
NCT01480310
First received: November 23, 2011
Last updated: August 4, 2014
Last verified: August 2014
  Purpose

This is a Phase Ia, randomized, double-blind, placebo-controlled, single ascendi ng dose (SAD) study in male and female healthy volunteers, aged 18-55 years, enr olled at a single study site in Canada.


Condition Intervention Phase
Healthy Volunteer
Drug: MCAF5352A
Drug: Placebo
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: A Phase Ia, Single-Center, Randomized, Placebo-Controlled, Double-Blind, Single Ascending-Dose Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of Subcutaneous MCAF5352A in Healthy Volunteers

Further study details as provided by Genentech:

Primary Outcome Measures:
  • Incidence of adverse events [ Time Frame: up to approximately 100 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Pharmacokinetic: maximum serum concentration (Cmax) [ Time Frame: up to approximately 100 days ] [ Designated as safety issue: No ]
  • Pharmacokinetic: time to maximum serum concentration (tmax) [ Time Frame: up to approximately 100 days ] [ Designated as safety issue: No ]
  • Pharmacokinetic: apparent clearance (CL/F) [ Time Frame: up to approximately 100 days ] [ Designated as safety issue: No ]
  • Pharmacokinetic: Terminal half-life (t½) [ Time Frame: up to approximately 100 days ] [ Designated as safety issue: No ]

Enrollment: 23
Study Start Date: December 2011
Study Completion Date: June 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: A Drug: MCAF5352A
may receive up to 3 subcutaneous doses of MCAF5352A
Experimental: B Drug: Placebo
may receive up to 3 subcutaneous doses of placebo

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Total body weight between 45 and 110 kg
  • Vital signs within the following ranges: oral body temperature of 35°C to 37.5°C, systolic blood pressure of 90 to 140 mmHg, diastolic blood pressure of 50 to 90 mmHg, and pulse rate of 45 to 100 bpm
  • Laboratory test parameters within normal reference ranges of the safety laboratory
  • Female subjects: Willing to use two effective methods of contraception from screening to a minimum of 4 months after the last dose of study drug. Reliable forms of contraception include oral hormonal contraceptives, patch hormonal contraceptives, vaginal ring, intrauterine device, physical double-barrier methods, surgical hysterectomy, or vasectomy by male partner.

Exclusion Criteria:

  • Pregnant or lactating women
  • Administration of a live, attenuated vaccine within 30 days before Day 1 or anticipation that such a live attenuated vaccine will be required within 100 days of Day 1 Subjects may receive influenza vaccination only during influenza season (approximately October to March). Subjects must not receive live attenuated influenza vaccine within 30 days prior to Day 1 or at any time during the study.
  • Any major illness within 30 days prior to Day 1
  • Clinically significant illness requiring treatment within 14 days prior to Day 1
  • History of clinically significant ECG abnormalities or a known family history of cardiac conduction system disease
  • Positive test results indicating current or past infection with human immunodeficiency virus (HIV-1 or 2), hepatitis B virus (hepatitis B surface antigen [HBsAg], hepatitis B core antibody [anti-HBc]), or hepatitis C virus (HCV)
  • Positive screening test for latent mycobacterial infection within the 2 months preceding Day 1 without evidence of a completed course of anti-tubercular therapy or previous BCG vaccination
  • History of significant chronic or recurrent infections
  • History of clinically significant drug allergy and/or a known hypersensitivity to protein therapeutics or formulation components or a related drug
  • History of alcohol or drug abuse within 12 months prior to Day 1, or evidence of such abuse as indicated by the specific screening laboratory tests results, or alcohol consumption of more than 14 units of alcohol per week
  • Positive breathalyzer for alcohol or urine screen results for drugs of abuse, or prescription medications
  • Subjects who have previously received the study drug
  • Participation in a clinical trial within 4 weeks before Day 1 or use of any experimental or biologic therapy within the 12 weeks prior to Day 1 or within 5 half-lives of the product, whichever is greater
  • Use of prescription drugs within 14 days prior to Day 1 or during the study, except for hormonal contraceptives or hormone replacement therapy
  • Use of over-the-counter (OTC) medication within 7 days prior to Day 1 or during the study. Medications such as acetaminophen and ibuprofen and routinely-taken dietary supplements, including vitamins and herbal supplements are allowed at the discretion of the investigator and provided that the medication in question has no discernible impact on the study.
  • Donation of plasma within 7 days prior to Day 1. Donation or loss of blood of 50 mL to 499 mL of blood within 30 days, or more than 499 mL within 56 days prior to Day 1.
  • Lack of peripheral venous access
  • Known history of mental illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01480310

Locations
Canada
Quebec, Canada, G1P 0A2
Sponsors and Collaborators
Genentech
Investigators
Study Director: Clinical Trials Genentech
  More Information

No publications provided

Responsible Party: Genentech
ClinicalTrials.gov Identifier: NCT01480310     History of Changes
Other Study ID Numbers: GA27909
Study First Received: November 23, 2011
Last Updated: August 4, 2014
Health Authority: Canada: Health Canada

ClinicalTrials.gov processed this record on August 21, 2014