Trial record 6 of 36 for:    "Prader-Willi syndrome"

Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Willi Syndrome

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT01479322
First received: July 31, 2011
Last updated: November 23, 2011
Last verified: November 2011
  Purpose

Context: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.

Objectives: To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.


Condition
Prader-Willi Syndrome
Obesity

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Correlation Between Hyperghrelinemia and Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome

Resource links provided by NLM:


Further study details as provided by Samsung Medical Center:

Enrollment: 51
Study Start Date: January 2007
Study Completion Date: July 2007
Detailed Description:

Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.

  Eligibility

Ages Eligible for Study:   6 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The investigators studied twenty-seven children with PWS and 24 normal control subjects. The groups were adjusted for age, sex, and BMI.

Criteria

Inclusion Criteria:

  • obesity with PWS

Exclusion Criteria:

  • chronic disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01479322

Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Dong-Kyu Jin, M.D Samsung Medical Center, Sungkyunkwan University School of Medicine
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01479322     History of Changes
Other Study ID Numbers: 2006-11-056
Study First Received: July 31, 2011
Last Updated: November 23, 2011
Health Authority: South Korea: Institutional Review Board

Keywords provided by Samsung Medical Center:
Intima-media thickness
Ghrelin
Prader-Willi syndrome

Additional relevant MeSH terms:
Prader-Willi Syndrome
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Mental Retardation
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on April 15, 2014