PEEP Recruitment-comparison Between Ultrasonographic Assessment and LIP Assessment

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Bojan Rode, Sisters of Mercy University Hospital
ClinicalTrials.gov Identifier:
NCT01478217
First received: November 20, 2011
Last updated: November 22, 2011
Last verified: November 2011
  Purpose

The purpose of this study is to compare lung recruitment in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) based on lower inflection point with transthoracic ultrasonographic assessment of lung recruitment.


Condition
Acute Respiratory Distress Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Positive End-expiratory Pressure Induced Lung Recruitment -Comparison Between Ultrasonographic Assessment and Lower Inflection Point Assessment on the Pressure -Volume Loop

Further study details as provided by Sisters of Mercy University Hospital:

Enrollment: 17
Study Start Date: October 2009
Study Completion Date: November 2011
Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Detailed Description:

Sedated and sometimes temporary relaxed patients with ALI/ARDS on mechanical ventilation in semirecumbent position are included. Lower inflection point on pressure volume loop on ventilator Draeger Evita 4 with low continuous flow on volume controlled ventilation is measured with zero PEEP. Transthoracic lung ultrasound with linear probe is proceed on both hemithoraces when mechanical ventilation based on measured PEEP is started. We compare if real lung recruitment seen by ultrasound is the same as predicted by lower inflection point.

The procedure is a part of routine everyday respiratory monitoring in our unit.

  Eligibility

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

intensive care patients

Criteria

Inclusion Criteria:

  • patients with diffuse ALI/ARDS on mechanical ventilation with visible lower inflection point on dynamic P-V loops

Exclusion Criteria:

  • preexisting parenchymal or pleural lung disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01478217

Locations
Croatia
Central intensive care unit, University hospital "Sisters of Mercy"
Grad Zagreb, Croatia, 10000
Sponsors and Collaborators
Sisters of Mercy University Hospital
Investigators
Principal Investigator: Bojan Rode, M.D.
  More Information

Publications:
Responsible Party: Bojan Rode, dr.med., Sisters of Mercy University Hospital
ClinicalTrials.gov Identifier: NCT01478217     History of Changes
Other Study ID Numbers: Vinogradska29
Study First Received: November 20, 2011
Last Updated: November 22, 2011
Health Authority: Croatia: Ethics Committee

Keywords provided by Sisters of Mercy University Hospital:
lung ultrasonography
pressure-volume loops
ARDS

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury

ClinicalTrials.gov processed this record on July 23, 2014