Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder (CFS:M)

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified May 2012 by Columbia University
Sponsor:
Information provided by (Responsible Party):
Alfred E. Slonim, Columbia University
ClinicalTrials.gov Identifier:
NCT01471652
First received: November 9, 2011
Last updated: May 31, 2012
Last verified: May 2012
  Purpose

The pathogenesis of chronic fatigue syndrome (CFS) is poorly understood and no effective therapy has been developed. Recent studies suggest that a preceding viral infection causes mitochondrial dysfunction of the brain and skeletal muscle of genetically susceptible individuals. There is no specific laboratory test to identify patients with CFS. However, certain clinical manifestations are similar to those seen in mitochondrial disorders. Both patients with mitochondrial disorders and CFS manifest elevated serum lactate levels after exercise, and demonstrate elevated brain cerebrospinal fluid levels and decreased brain glutathione levels on nuclear magnetic resonance (NMR) spectroscopy.

Therapy consisting of daily conditioning exercise, dietary recommendations, and nutraceutical supplements (ENT) has been show to be beneficial in treating patients with mitochondrial disorders. Similar therapy has been instituted in individual patients with CFS and has been shown to also improve their clinical conditions.

A placebo-controlled trial will be undertaken in 24 CFS patients aged 25-55. Patients fulfilling the CDC criteria for CFS will participate in this 6 month study. Other medical causes for fatigue will be excluded. Half the patients will receive treatment consisting of daily conditioning exercise plus nutraceutical supplements (ENT), that has been shown to be beneficial for patients with mitochondrial dysfunction, while the other half will receive daily conditioning exercise and placebo tablets. Response to ENT will be evaluated by maximum oxygen consumption (VO2max) and circulating lactate levels during & after treadmill exercise, a 6-minute walk test, and a fatigue questionnaire. In addition, whether ENT corrects the elevated brain cerebrospinal fluid levels and decreased brain glutathione levels will be measured. To ensure compliance to therapy patients will be monitored frequently. The objective of this study is to assess the safety and efficacy of ENT and whether ENT leads to sustained improvement of CFS patients compared to their baseline status, and compared to an exercised group of patients not receiving supplements.


Condition Intervention Phase
Chronic Fatigue Syndrome
Drug: Nutraceutical supplements
Drug: Placebo
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Chronic Fatigue Syndrome: Correction of Mitochondrial Dysfunction by Conditioning Exercise and Nutraceutical Therapy.

Resource links provided by NLM:


Further study details as provided by Columbia University:

Primary Outcome Measures:
  • Change in rate of fatigue status and other CFS symptoms [ Time Frame: 0, 3, and 6 months ] [ Designated as safety issue: No ]
    Rate of decrease in fatigue and other CFS symptoms, as measured by SF-36 and The Fatigue Assessment Instrument.


Secondary Outcome Measures:
  • Change in brain lactate and glutathione levels [ Time Frame: 0 and 6 months ] [ Designated as safety issue: No ]
    Patients will undergo nuclear magnetic resonance spectroscopy of the brain prior to starting therapy (baseline) and repeat it after 6 months of therapy.


Estimated Enrollment: 24
Study Start Date: September 2012
Estimated Study Completion Date: September 2014
Estimated Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Nutraceuticals
Subjects will receive a combination of 4 nutraceuticals (CoEnzyme Q10, acetyl-L-carnitine, alpha-lipoic acid, docosahexaenoic acid (DHA)) and a multivitamin.
Drug: Nutraceutical supplements
  1. CoEnzyme Q10: oral gel capsule bid
  2. Acetyl L-carnitine: oral capsule bid
  3. Alpha Lipoic Acid: oral tablet qd
  4. Docosahexaenoic acid: oral gel capsule bid
Placebo Comparator: Placebo Drug: Placebo

Capsule form to imitate the following nutraceuticals:

  1. Placebo 1: oral gel capsule bid
  2. Placebo 2: oral capsule bid
  3. Placebo 3: oral tablet qd
  4. Placebo 4: oral gel capsule bid

Detailed Description:

Chronic fatigue syndrome (CFS), also known as myalgic encephalitis (ME), is clinically characterized as a multisystem illness exhibiting debilitating fatigue, musculoskeletal pain, disturbed sleep, and impaired memory and concentration. Its diagnosis is non-specific and symptom based, with no real biomarkers yet identified. The etiology and pathophysiology of CFS remain obscure. There is a long-standing hypothesis that individuals with CFS have normal metabolism and their fatigue is psychological, with energy being wasted through the processes of anxiety, stress, and depression. The more CFS is investigated, however, the clearer it becomes that this is incorrect, and that it is probably a metabolic dysfunction resulting in insufficient energy production. A number of studies have suggested that there may be a genetic contribution to CFS. In addition, a severe viral illness frequently predisposes the onset of CFS, while a number of pathogens have been linked to CFS (2, 3, 6). Although some patients develop CFS after an acute infection such as mononucleosis, some investigators believe it arises from the reactivation of a latent virus in the host, both resulting in a chronic low-level activation of the immune system.

As more data are acquired, we and others believe that CFS is actually a metabolic mitochondrial dysfunction resulting in insufficient energy production. Mounting evidence indicates that viral infections in genetically susceptible individuals can cause changes in mitochondrial function. Many features observed in CFS are similar to those seen in genetic mitochondrial disorders. Firstly, some muscle biopsies in patients with CFS have shown both abnormal mitochondrial degeneration and severe deletions of mitochondrial DNA genes. Mitochondrial dysfunction increases the production of free radicals and reactive oxygen species (ROS), which cause oxidative damage, believed to contribute to CFS pathogenesis. Carnitine is required for metabolic reactions including mitochondrial fatty acid oxidation. A deficiency of serum acylcarnitine has been observed in CFS patients, suggesting that there is increased utilization of carnitine in CFS, thereby decreasing energy production. In mitochondrial disorders, utilization of pyruvate is decreased, resulting in higher circulating and muscle levels of lactate, as well as decreased oxidative phosphorylation and energy production. Brain ventricular cerebrospinal lactate is elevated, and brain glutathione is decreased, in both mitochondrial disorders and CFS. In CFS patients cerebrospinal lactate is increased by approximately 300% compared to that found in generalized anxiety disorder and healthy individuals. Using brain NMR spectroscopy, the distinction between CFS and psychological disorders can be demonstrated.

  Eligibility

Ages Eligible for Study:   25 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Subjects must meet the criteria for CFS of the US Centers for Disease Control and Prevention (CDC), which requires persistent, unexplained fatigue for at least 6 months, concurrent with four of the following:

  • impaired memory/concentration
  • sore throat, new headaches
  • unrefreshing sleep, muscle pain
  • multi-joint pain
  • tender lymph nodes
  • post-exertional malaise

As well, due to the frequency of visits subjects must currently reside in the greater New York area.

Exclusion Criteria:

  • shortness of breath
  • heart disease
  • high blood pressure
  • other severe chronic illnesses
  • clinical depression
  • generalized anxiety disorder
  • insomnia
  • inflammatory arthritis
  • anemia
  • hypothyroidism
  • other conditions associated with significant fatigue
  • history of alcohol, tobacco, or drug abuse
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01471652

Contacts
Contact: Alfred E Slonim, MD 212-305-5717 as2718@columbia.edu

Locations
United States, New York
Columbia University Department of Clinical Genetics Not yet recruiting
New York, New York, United States, 10032
Principal Investigator: Alfred E Slonim, MD         
Sponsors and Collaborators
Alfred E. Slonim
Investigators
Principal Investigator: Alfred E Slonim, MD Columbia University
  More Information

No publications provided

Responsible Party: Alfred E. Slonim, Professor of Clinical Pediatrics, Columbia University
ClinicalTrials.gov Identifier: NCT01471652     History of Changes
Other Study ID Numbers: AAAJ0702
Study First Received: November 9, 2011
Last Updated: May 31, 2012
Health Authority: United States: Food and Drug Administration
United States: Institutional Review Board

Keywords provided by Columbia University:
myalgic encephalopathy
chronic fatigue syndrome
post viral infection
fatigue
muscle pain
unrefreshing sleep
fuzzy thought
poor memory
forgetfulness

Additional relevant MeSH terms:
Fatigue
Fatigue Syndrome, Chronic
Mitochondrial Diseases
Signs and Symptoms
Virus Diseases
Muscular Diseases
Musculoskeletal Diseases
Encephalomyelitis
Central Nervous System Diseases
Nervous System Diseases
Neuromuscular Diseases
Metabolic Diseases
Acetylcarnitine
Thioctic Acid
Vitamin B Complex
Vitamins
Micronutrients
Growth Substances
Physiological Effects of Drugs
Pharmacologic Actions
Nootropic Agents
Central Nervous System Agents
Therapeutic Uses
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents

ClinicalTrials.gov processed this record on August 21, 2014