Relation of Glucose and Acute Pancreatitis (ROGAAP)

This study has been completed.
Sponsor:
Collaborator:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Information provided by (Responsible Party):
xiaolong zhao, Huashan Hospital
ClinicalTrials.gov Identifier:
NCT01470885
First received: November 9, 2011
Last updated: May 2, 2014
Last verified: May 2014
  Purpose

Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Part of endocrine function of pancreas would be affected in AP. Stress hyperglycemia would explode at acute phase. So the investigators decide to follow up and observe 200 cases of patients with acute pancreatitis, determining of blood sugar, blood amylase, hemoglobin and glycosylated hemoglobin level. At last, using ROC curve method to identify the die cutting between blood glucose level and acute pancreatitis, and makes analysis of the diagnostic value.


Condition
Acute Pancreatitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: the Influence of Glucose to the Prognosis of Patients of Acute Pancreatitis

Resource links provided by NLM:


Further study details as provided by Huashan Hospital:

Primary Outcome Measures:
  • motability [ Time Frame: motability ] [ Designated as safety issue: No ]
    motability after acute pancreatitis


Enrollment: 350
Study Start Date: March 2011
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
glucose value
glucose value

Detailed Description:

Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Part of endocrine function of pancreas would be affected in AP. Stress hyperglycemia would explode at acute phase. There are two reasons. One is because that sympathetic hyperactivity makes glucagon elevated. Secondary, microcirculation disorder makes pancreas edema, ischemia and necrosis, affecting secretion and excretion of insulin. In severe acute pancreatitis, there may be ketoacidosis. Many scoring systems for predicting prognosis of severe acute pancreatitis also contains glucose values, such as the Ranson scoring system and the Glascow scoring system. On the other hand, Type 2 diabetes has become a global pandemic disease. Most of patients of type 2 diabetes are obese, who easily complicated gallstone disease and hypertriglyceridemia. All of above could be the risk factors for acute pancreatitis. Our initial small sample research also suggests undiagnosed diabetes patients whose glucose value elevated is significantly worse than the known diabetic patients. Therefore, the investigators believe that glucose directly affects the prognosis of AP. So the investigators decide to follow up and observe 1000 cases of patients with acute pancreatitis, determining of blood sugar, blood amylase, hemoglobin and glycosylated hemoglobin level. At last, using ROC curve method to identify the die cutting between blood glucose level and acute pancreatitis, and makes analysis of the diagnostic value.

  Eligibility

Ages Eligible for Study:   15 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

primary care clinic

Criteria

Inclusion Criteria:

patients that newly diagnosed as acute pancreatitis.

Exclusion Criteria:

exclude other acute abdomen, such as peptic ulcer with perforation, mesenteric arterial embolism or ruptured ectopic pregnancy.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01470885

Locations
China, Shanghai
Xiaolong Zhao
Shanghai, Shanghai, China, 21012
Sponsors and Collaborators
Huashan Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
  More Information

Publications:
Responsible Party: xiaolong zhao, endocrinology department, Huashan Hospital
ClinicalTrials.gov Identifier: NCT01470885     History of Changes
Other Study ID Numbers: zsdxxhnk20110707
Study First Received: November 9, 2011
Last Updated: May 2, 2014
Health Authority: China: Ministry of Health

Keywords provided by Huashan Hospital:
glucose
prognosis
glycated hemoglobin

Additional relevant MeSH terms:
Pancreatitis
Pancreatic Diseases
Digestive System Diseases

ClinicalTrials.gov processed this record on August 28, 2014