Event Related Potentials in Borderline Personality Disorder and Major Depression
This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder.
Unlike people who have depression alone (i.e. without borderline personality disorder), people with borderline personality disorder have depressions that often do not improve with medications. This makes treating depression much more challenging in someone with borderline personality disorder than without borderline personality disorder.
Borderline personality disorderis associated with difficulty in understanding and communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the brain, the anterior cingulate.
Depression is associated with changes in anterior cingulate activity. The investigators believe that when borderline personality disorder is present with depression, brain activity changes in the anterior cingulate will not be the same as in depressed patients without borderline personality disorder.
An electroencephalogram records brain electrical activity. In this study, the investigators will measure electroencephalogram indices reflecting anterior cingulate activity.
HYPOTHESIS: In this study, the investigators predict that when borderline personality is present with depression, electroencephalogram indices of anterior cingulate activity will be different from when depression is present alone (without borderline personality). This could help to explain why people with borderline personality have depressions that are harder to treat than depressions in people without borderline personality.
The investigators also predict that electroencephalogram indices of the anterior cingulate will reflect emotional processing ability, as measured by validated questionnaires.
Borderline Personality Disorder
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Event Related Potentials in Borderline Personality Disorder and Major Depression|
- Error related negativity amplitude [ Time Frame: on day 1 and then 4 weeks (average) later ] [ Designated as safety issue: No ]electroencephalogram amplitude of the error related negativity
- N2 amplitude [ Time Frame: on day 1 and then 4 weeks (average) later ] [ Designated as safety issue: No ]electroencephalogram amplitude of N2 wave
|Study Start Date:||July 2011|
|Estimated Study Completion Date:||March 2013|
|Estimated Primary Completion Date:||March 2013 (Final data collection date for primary outcome measure)|
Healthy participants without borderline personality or depression
Major Depression, No Borderline Personality Disorder
With major depression and no borderline personality
Major Depression + Borderline Personality Disorder
With major depression and borderline personality disorder
No Major Depression, Borderline Personality Disorder
With no major depression, but with borderline personality disorder
|Contact: Amruthur G Ramamurthy, MD||315 464 email@example.com|
|Contact: Robert Gregory, MD||315 464 firstname.lastname@example.org|
|United States, New York|
|Upstate Medical University||Recruiting|
|Syracuse, New York, United States, 13210|
|Contact: Amruthur Ramamurthy, MD 315-464-5668 email@example.com|
|Principal Investigator: Amruthur Ramamurthy, MD|
|Sub-Investigator: Robert Gregory, MD|
|Sub-Investigator: Dennis Bogin, PhD|
|Sub-Investigator: Wendy Kates, PhD|
|Sub-Investigator: Tarakad Ramachandran, PhD|
|Sub-Investigator: Kelly Wallace|
|Sub-Investigator: Petya Radoeva|
|Sub-Investigator: Laura A Miller|
|Sub-Investigator: Eric MacMaster, MD|
|Syracuse University - CNY Medical Center||Not yet recruiting|
|Syracuse, New York, United States, 13078|
|Contact: Ramamurthy firstname.lastname@example.org|
|Sub-Investigator: Stephanie Ortigue, PhD|
|Principal Investigator:||Amruthur Ramamurthy, MD||State University of New York - Upstate Medical University|