Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft (MJRUVCBG)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Xu Zhang, The Second Hospital of Qinhuangdao
ClinicalTrials.gov Identifier:
NCT01467752
First received: November 2, 2011
Last updated: November 8, 2011
Last verified: November 2011
  Purpose

Traumatic cartilage loss of the joint is central to the development of joint failure in arthritis. The study on the use of a bone graft for reconstruction of metacarpophalangeal joint defects.


Condition Intervention Phase
Volar Plate Injury, Thumb, Metacarpophalangeal Joint
Procedure: MCP joint
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Phase 1 Study for Reconstruction of Metacarpophalangeal Joint Using a Vascularized Cartilage and Bone Graft From the Third Metacarpal

Resource links provided by NLM:


Further study details as provided by The Second Hospital of Qinhuangdao:

Primary Outcome Measures:
  • Range of motion; Arm, Shoulder and Hand questionnaire [ Time Frame: 4 years ] [ Designated as safety issue: Yes ]
    The active motions of the hand were measured by a goniometer. The patients rated their MCP joint pain, the donor joint pain, and scar pain using a line by a visual analogue scale (VAS). We used the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire to assess the hand function.


Secondary Outcome Measures:
  • Pain [ Time Frame: 4 years ] [ Designated as safety issue: Yes ]
    joint pain is assessed using visual analogue scale


Enrollment: 15
Study Start Date: January 2005
Study Completion Date: December 2009
Primary Completion Date: January 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: MCP joint
reconstruction of metacarpophalangeal (MCP) joint
Procedure: MCP joint
reconstruction of metacarpophalangeal (MCP) joint using a bone graft
Other Name: MCP joint reconstruction

Detailed Description:

The metacarpophalangeal joint is vital for hand function. Cartilage loss of the joint is central to the development of joint failure in arthritis. Although various treatments have been proposed, the management remains a challenging problem.Previous anatomical studies have shown that, at the base of the metacarpal, there were nutrient arteries inserting into the dorsum of the metacarpal. The nutrient arteries arise from the distal and middle dorsal carpal arches that run distally to the first to fourth dorsal metacarpal arteries (DMAs. These studies prompt us to use a reverse vascularized cartilage and bone graft based on the DMA. The metacarpal consists of a widened proximal base. The joint surface to the capitate is convex anteriorly and dorsally concave, where it extends to the styloid process on the dorsolateral aspect of the metacarpal base. The unique contour stimulates our imagination and creativity to use a portion of the joint surface for reconstruction of metacarpophalangeal joint defects. The purpose of this study is to report the novel technique and to evaluate the effectiveness of the treatment.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. a cartilage defect at either proximal or distal MCP joint;
  2. either an acute or old injury;
  3. loss of 1/4 of joint entire surface that seen on plain radiographs, CT scan, and intraoperative finding;
  4. and with or without MCP joint subluxation.

Exclusion Criteria:

  1. large defects involved double joint surfaces;
  2. the size of the defect involving less than 1/4 of the joint surface;
  3. associate with infection or other diseases that restrict to use the technique.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01467752

Locations
China, Hebei
The second hospital of Qinhuangdao
Qinhuangdao, Hebei, China, 066600
Sponsors and Collaborators
The Second Hospital of Qinhuangdao
Investigators
Study Chair: Xu Zhang, MD The Second Hospital of Qinhuangdao
  More Information

Additional Information:
Publications:
Responsible Party: Xu Zhang, Director, The Second Hospital of Qinhuangdao
ClinicalTrials.gov Identifier: NCT01467752     History of Changes
Other Study ID Numbers: XZhang201111, SHQ
Study First Received: November 2, 2011
Last Updated: November 8, 2011
Health Authority: China: Ethics Committee

Keywords provided by The Second Hospital of Qinhuangdao:
reconstruction
metacarpophalangeal joint
bone graft
MCP joint

Additional relevant MeSH terms:
Wounds and Injuries

ClinicalTrials.gov processed this record on July 24, 2014