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Health Benefits of Chronic vs. Acute Exercise in Overweight Adults

This study is currently recruiting participants.
Verified December 2012 by University of Michigan
Sponsor:
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by (Responsible Party):
JEFFREY F HOROWITZ, University of Michigan
ClinicalTrials.gov Identifier:
NCT01452087
First received: October 11, 2011
Last updated: December 14, 2012
Last verified: December 2012
History of Changes
  Purpose

Compare the effects of single session of exercise vs. chronic exercise training on key risk factors associated with Metabolic Syndrome (e.g., glucose tolerance, blood lipid profile, and blood pressure) in overweight adults.


Condition Intervention
Obesity
 Other: Exercise

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Michigan:

Primary Outcome Measures:
  • oral glucose tolerance test [ Time Frame: 2 hour ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Resting Metabolic Rate [ Time Frame: 20-30 min ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: May 2009
Estimated Study Completion Date: February 2013
Estimated Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Exercise Session
Subjects will exercise on a treadmill for 1 hour at moderate intensity (i.e., 90% of the exercise intensity found to elicit their ventilatory threshold during the preliminary testing, which is equivalent to approximately 60% of their maximal predicted heart rate).
 Other: Exercise
Subjects will exercise on a treadmill for 1 hour at moderate intensity (i.e., 90% of the exercise intensity found to elicit their ventilatory threshold during the preliminary testing, which is equivalent to approximately 60% of their maximal predicted heart rate).

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Body Mass Index: 27-34 kg/m2;
  • Regular exercisers(≥4 days/wk of aerobic exercise;
  • 30-60min/session at moderate and vigorous intensities);
  • Non-exercisers (no regularly planned exercise/physical activity);
  • Women must have regularly occurring menses and must be premenopausal.

Exclusion Criteria:

  • Pregnant or lactating;
  • Evidence/history of cardiovascular or metabolic disease;
  • Currently taking medications known to affect lipid or glucose metabolism.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01452087

Contacts
Contact: Suzette Howton, RD 734-647-9850 suzetter@med.umich.edu

Locations
United States, Michigan
Substrate Metabolism Laboratory Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Suzette Howton, RD     734-647-9850     suzetter@med.umich.edu    
Principal Investigator: Jeffrey F Horowitz, Ph.D.            
Sponsors and Collaborators
University of Michigan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Investigators
Principal Investigator: Jeffrey F Horowitz, Ph.D. University of Michigan
  More Information

No publications provided

Responsible Party: JEFFREY F HOROWITZ, Associate Professor, Movement Science, School of Kinesiology, University of Michigan
ClinicalTrials.gov Identifier: NCT01452087     History of Changes
Other Study ID Numbers: R01 DK077966 - R, R01DK077966
Study First Received: October 11, 2011
Last Updated: December 14, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by University of Michigan:
insulin sensitivity
exercise

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
 Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on June 17, 2013