Human Skin Aging: Clinical Parameters and Gene Expression Profiling (GEP)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Anne Chang, Stanford University Identifier:
First received: October 11, 2011
Last updated: December 2, 2013
Last verified: December 2013

Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.


Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Assessment of age related gene expression changes in skin [ Time Frame: Cross sectional ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Blood and skin samples

Estimated Enrollment: 120
Study Start Date: May 2010
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Healthy females aged >=18
Healthy female volunteers of skin type I or II

Detailed Description:

This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy females age 18 or older


Inclusion Criteria:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

Exclusion Criteria:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks
  Contacts and Locations
Please refer to this study by its identifier: NCT01451476

United States, California
Stanford Dermatology
Redwood City, California, United States, 94603
Sponsors and Collaborators
Stanford University
Principal Investigator: Alfred Lane, MD Stanford University
Study Director: Anne Chang, MD Stanford University
  More Information

No publications provided

Responsible Party: Anne Chang, instructor, Stanford University Identifier: NCT01451476     History of Changes
Other Study ID Numbers: HSA_GEP, 003
Study First Received: October 11, 2011
Last Updated: December 2, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Stanford University:
Ageing processed this record on April 17, 2014