Predictors of Postoperative Pain
The purpose of the study is to prove that pain scores generated from painful stimuli applied preoperatively may help identify the inter-individual variability in pain perception.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Supportive Care
|Official Title:||Predictors of Postoperative Pain Following Abdominal Hysterectomy|
- pain scores from IV insertion [ Time Frame: 15 minutes prior to induction ] [ Designated as safety issue: No ]
- Anxiety [ Time Frame: 24 to 48 hours before surgery ] [ Designated as safety issue: No ]
- Pain from thermal stimuli [ Time Frame: 24 to 48 hours before surgery ] [ Designated as safety issue: No ]Pain from thermal stimuli will be measure at two sites: site of surgery and at the forearm.
- Suprathreshold Thermal pain intensity [ Time Frame: 24 to 48 hours before surgery ] [ Designated as safety issue: No ]Suprathreshold Thermal pain intensity will be recorded at two site: site of surgery and forearm
- suprathreshold thermal unpleasantness intensity [ Time Frame: 24 to 48 hours before surgery ] [ Designated as safety issue: No ]
- Expectation about pain [ Time Frame: 24 to 48 hours before surgery ] [ Designated as safety issue: No ]
- postoperative pain [ Time Frame: five minutes before morphine administration and 15 minutes after morphine administration in the PACU, upon discharge from PACU, and at 12 hours, 24 hours, 36 hours and 48 hours after discharge from PACU ] [ Designated as safety issue: No ]Postoperative pain will be measured upon arrival to the Post Anesthesia Care Unit (PACU)before morphine consumption and after morphine consumption, at rest and at movement.
- Morphine consumption [ Time Frame: Upon discharge from PACU, at 12 hours, 24 hours, 36 hours and 48 hours after discharge from PACU ] [ Designated as safety issue: No ]
|Study Start Date:||July 2012|
|Estimated Study Completion Date:||October 2012|
|Estimated Primary Completion Date:||October 2012 (Final data collection date for primary outcome measure)|
Device: Thermal Sensory Analyzer (Senselab)
Thermal stimuli will be administered to the ventral surface of the dominant forearm and then to the lower abdomen (surgical site)using the Thermal Sensory Analyser. Each thermal testing trial will be separated by approximately 2 min and at a separate site.
To measure the thermal pain threshold temperature, The thermode will be applied to the ventral surface of the dominant forearm and the temperature will be increased at 1°C/s from 35 to 50°C.
To measure the Suprathreshold Thermal Pain Intensity and unpleasantness, Stimulus responses for noxious heat stimuli will be performed by applying phasic heat stimuli at 8 different temperatures (35, 43, 44, 45, 46, 47, 48, and 49°C).
Psychological factors and experimental pain models such as as electrical, pressure, heat, or cold stimuli have been identified as predictors of pain intensity and opioid consumption postoperatively. This study will investigate, in addition to the factors described above, the ability of pain scores generated from painful stimuli postoperatively in predicting postoperative pain.
|Contact: Marie T Aouad, MD||961-1-350000 ext email@example.com|
|American Unversity of Beirut Medical Center||Recruiting|
|Contact: Marie T Aouad, MD 961-1-350000 ext 6380 firstname.lastname@example.org|
|Contact: Badiaa Masri, MPH 961-1350000 ext 6368 email@example.com|
|Principal Investigator: Marie T Aouad, MD|
|Sub-Investigator: Ghassan E Kanazi, MD|
|Sub-Investigator: Krystel Malek, MD|
|Sub-Investigator: Muhieddine Seoud, MD|
|Sub-Investigator: Badiaa Masri, MPH|
|Principal Investigator:||Marie T Aouad, MD||American University of Beirut Medical Center|