Transient Ischemic Attack (TIA) Triage and Evaluation of Stroke Risk
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
Transient ischemic attack (TIA) is a transient neurological deficit (speech disturbance, weakness…), caused by temporary occlusion of a brain vessel by a blood clot that leaves no lasting effect.
TIA diagnosis can be challenging and an expert stroke evaluation combined with magnetic resonance imaging (MRI) could improve the diagnosis accuracy.
The risk of a debilitating stroke can be as high as 5% during the first 72 hrs after TIA.
TIA characteristics (duration, type of symptoms, age of the patient), the presence of a significant narrowing of the neck vessels responsible for the patient's symptoms (symptomatic stenosis), and an abnormal MRI are associated with an increased risk of stroke.
An emergent evaluation and treatment of TIA patients by a stroke specialist could reduce the risk of stroke to 2%.
Stanford has implemented an expedited triage pathway for TIA patients combining a clinical evaluation by a stroke neurologist, an acute MRI of the brain and the vessels and a sampling of biomarkers (Lp-PLA2). The investigators are investigating the yield of this unique approach to improve TIA diagnosis, prognosis and secondary stroke prevention. The objective of this prospective cohort study is to determine which factors will help the physician to confirm the diagnosis of TIA and to define the risk of stroke after a TIA.
| Condition |
|---|
|
Cerebrovascular Accident |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | TIA Triage Trial and Evaluation of Vascular-Specific Inflammatory BiomarkerLp-PLA2 as a Stratification Tool for TIA Triage and Stroke Risk |
- vascular events [ Time Frame: 90 days ] [ Designated as safety issue: No ]
- Vascular Events [ Time Frame: 7 days ] [ Designated as safety issue: No ]
- Vascular Events [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
2 tiger top or gold top tubes
- Blood specimens should be inverted 10 times before processing.
- Centrifuge and separate within four hours of venipuncture.
- Transfer 1.0 ml into 2 transfer tubes
Freeze at -70 C
| Estimated Enrollment: | 400 |
| Study Start Date: | September 2010 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
Show Detailed Description Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Probability Sample |
Patients admitted to the ED with symptoms of acute TIA
Inclusion Criteria:
- Men and Women age greater than 18 year old
- Symptoms suggestive of an acute TIA
Exclusion Criteria:
- Patients with contraindication to brain imaging: MRI and CT.
- Patient with persistent major deficit (NIHSS> or = 4)
- Informed consent could not be obtained either directly from the patient or from legally authorized representative.
- Severe coexisting or terminal systemic disease with like expectancy below 90 days or that may interfere with the conduct of the study.
Contacts and Locations| Contact: Stephanie Kemp, BS | (650) 723-4481 | skemp@stanford.edu |
| United States, California | |
| Stanford University School of Medicine | Recruiting |
| Stanford, California, United States, 94305 | |
| Contact: Stephanie Kemp, BS 650-723-4481 skemp@stanford.edu | |
| Principal Investigator: Gregory W Albers | |
| Sub-Investigator: Mohamed Teleb | |
| Sub-Investigator: Waimei A Tai | |
| Sub-Investigator: Anna K. Finley Caulfield | |
| Sub-Investigator: Dr. chitra venkat | |
| Sub-Investigator: Paul Singh | |
| Sub-Investigator: Maarten G Lansberg MD, PhD | |
| Sub-Investigator: Neil Schwartz | |
| Sub-Investigator: Jean-Marc Olivot | |
| United States, Michigan | |
| Michigan State University | Recruiting |
| Grand Rapids, Michigan, United States, 49503 | |
| Contact: Michael Brown, MD 616-391-3050 brownm@msu.edu | |
| Principal Investigator: Michael Brown | |
| Principal Investigator: | Gregory W Albers | Stanford University |
More Information
Publications:
| Responsible Party: | Gregory W Albers, MD, Professor of Neurology, Stanford University |
| ClinicalTrials.gov Identifier: | NCT01423201 History of Changes |
| Other Study ID Numbers: | SU-08012011-8167, 19211 |
| Study First Received: | August 16, 2011 |
| Last Updated: | June 5, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Stanford University:
|
TIA triage Lp-PLA2 |
Additional relevant MeSH terms:
|
Ischemic Attack, Transient Cerebral Infarction Stroke Brain Ischemia Cerebrovascular Disorders Brain Diseases |
Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction |
ClinicalTrials.gov processed this record on May 23, 2013