Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects
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Purpose
The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.
| Condition | Intervention | Phase |
|---|---|---|
|
Diabetes Mellitus |
Other: Khalas dates |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Endpoint Classification: Bio-availability Study Intervention Model: Single Group Assignment Masking: Single Blind (Subject) |
| Official Title: | Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects |
- Glycemic Index of Khalas dates with and without coffee [ Time Frame: 2 or 3 hours ] [ Designated as safety issue: No ]Every subject recieved 50 grams reducing sugars of Khalas dates with and without coffee. Measuring glucose level over 2 hours in Healthy subjects and over 3 hours in diabetic subjects as per a standard protocol.
| Enrollment: | 23 |
| Study Start Date: | March 2010 |
| Study Completion Date: | June 2010 |
| Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: GI of Khalas dates
The Glycemic indices of the Khalas dates were measured for healthy and diabetic subjects.
|
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates
Other Name: Khalas dates
|
|
Experimental: GI of the Khalas dates with Coffee
measuring the effect of 100 ml of coffee consumption on the GI of the Khalas dates among healthy and diabetic subjects.
|
Other: Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates
Other Name: Khalas dates
|
Detailed Description:
Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.
Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.
Eligibility| Ages Eligible for Study: | 18 Years to 60 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c ≤8%) on diet with or without metformin
Exclusion Criteria:
- morbid obesity (BMI > 40 kg/m2)
- pre diabetes
- pregnancy
- presence of gastroenterological disorders
- alimentary tract surgery
- a history of gastroenteritis in the prior six months
- any alcohol intake
- smoking
- taking any medications (except metformin)
- poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases
Contacts and Locations| United Arab Emirates | |
| Faculty of Medicine and Health Sciences UAE University | |
| Al Ain, AB, United Arab Emirates | |
| Principal Investigator: | Juma M Alkaabi, MD | Assistant professor Internal Medicine Department FMHS UAE University |
| Study Chair: | Bayan Al-Dabbag, PhD | FMHS UAE university |
| Study Chair: | Hussein Saadi, MD | Professor of Medicine, FMHS UAE University |
| Study Chair: | Salah Gariballa, MD | Professor of Medicine FMHS UAE University |
| Study Chair: | Yasin Javed, Msc | FMHS UAE University |
More Information
No publications provided
| Responsible Party: | Juma Alkaabi, Assistant Professor of Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University |
| ClinicalTrials.gov Identifier: | NCT01422668 History of Changes |
| Other Study ID Numbers: | UAEU: GI Dates Study |
| Study First Received: | August 18, 2011 |
| Last Updated: | August 23, 2011 |
| Health Authority: | United Arab Emirates: Al Ain Medical District Human Research Ethics Committee United Arab Emirates: UAE University United Arab Emirates: SEHA |
Keywords provided by United Arab Emirates University:
|
Glycemic index Dates Diabetes Coffee |
Additional relevant MeSH terms:
|
Diabetes Mellitus Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases |
ClinicalTrials.gov processed this record on May 19, 2013