Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors|
- To measure time series of MRI imaging by the b-SSFP sequence. [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.
|Study Start Date:||September 2011|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Other: cine MRI
Rapid Cine-MRI for Monitoring Moving and Deforming Tumors
Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.
|Contact: Amit Sawant, Ph.D||214-645-8525|
|Contact: Jean Wu, MSN||214-645-8525|
|United States, Texas|
|UT Southwestern Medical Center||Recruiting|
|Dallas, Texas, United States, 75390|
|Principal Investigator: Amit Sawant, Ph.D.|
|Principal Investigator:||Amit Sawant, Ph.D.||UT Southwestern Medical Center|