Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients
Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya disease and stroke patients
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients|
- Arterial spin labeling in magnetic resonance imaging to assess collateral blood flow [ Time Frame: performed one time prior to surgery ] [ Designated as safety issue: No ]
|Study Start Date:||April 2009|
|Estimated Study Completion Date:||April 2014|
|Estimated Primary Completion Date:||April 2014 (Final data collection date for primary outcome measure)|
60 MOyamoya patients will be enrolled.
60 acute stroke patients will be enrolled
normal and diagnosis unspecified
A sub-group of 60 patient without specified diagnoses and 30 normals will be enrolled.
In the early hours following large vessel occlusion, the ultimate severity of the stroke is largely determined by the ability of collateral flow networks to supply blood to ischemic tissue via circuitous routes that bypass the proximal clot. Robust collateral flow can improve response to thrombolytic therapy and decrease the risk of intracranial hemorrhage. Despite their central importance, collaterals during acute stroke are poorly understood, largely because assessment has required an invasive imaging test, cerebral angiography. This proposal assesses whether a noncontrast MRI perfusion technique, called arterial spin labeling (ASL), can yield important information about collateral flow.
|Contact: Sandra Dunn||(650) email@example.com|
|United States, California|
|Stanford University School of Medicine||Recruiting|
|Stanford, California, United States, 94305|
|Contact: Sandra Dunn 650-724-8278 firstname.lastname@example.org|
|Principal Investigator: Greg Zaharchuk|
|Principal Investigator:||Greg Zaharchuk||Stanford University|