Cosmetic Evaluation of Lumpectomy Versus Oncolytic Mammoplasty With Bilateral Breast Reduction for Early Stage Breast Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2011 by New Hanover Regional Medical Center
Sponsor:
Collaborators:
Coastal Carolina Radiation Oncology (CCRO)
Information provided by:
New Hanover Regional Medical Center
ClinicalTrials.gov Identifier:
NCT01400399
First received: July 20, 2011
Last updated: August 10, 2011
Last verified: August 2011
  Purpose

This study will evaluate the cosmetic outcome and examine factors contributing to cosmetic outcome in women treated with lumpectomy or bilateral breast reduction mammoplasty/mastopexy (BRM) followed by hypofractionated whole breast irradiation. Breast conservation is now an established method of treatment for early breast cancer. Because breast conservation is essentially a cosmetic alternative to mastectomy, quality of life, cosmetic outcome and tumor control are all important considerations during comprehensive treatment planning. Irradiation schemes have been demonstrated to be efficacious and with excellent short term cosmetic outcomes. However, their interaction with currently evolving surgical techniques needs to be examined in order to maintain optimal local control while preserving cosmetic outcome.


Condition
Breast Carcinoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Phase II Evaluation of Hypofractionated Breast Irradiation in Patients Undergoing Standard Lumpectomy or Oncolytic Mammoplasty With Bilateral Breast Reduction

Resource links provided by NLM:


Further study details as provided by New Hanover Regional Medical Center:

Primary Outcome Measures:
  • Evaluation of cosmetic results as judged by the patient, surgeon and radiation oncologist at stated follow-up intervals that will judge cosmesis by serial photography and quality of life (QOL) forms. [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Ipsilateral breast recurrence rate. Disease status will be evaluated at routine patient follow-up appointments including routine mammography. [ Time Frame: 10 years ] [ Designated as safety issue: No ]
  • Contralateral breast cancer rate. This will be monitored according to routine protocol including yearly mammograms and clinical breast exams. [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 84
Study Start Date: August 2010
Estimated Study Completion Date: August 2020
Estimated Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Detailed Description:

Breast cancer outcomes and cosmesis may differ by race. Limited but controversial data suggests that African-American women have worse cosmetic outcomes with hypofractionated irradiation than with conventional breast conservation. A growing body of data also suggests that African-American women have diminished oncologic outcomes when compared to Caucasian women in the United States. Further evaluation is needed to better understand the reason for these discrepancies.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Breast cancer patients who have had a lumpectomy or bilateral reduction mammoplasty followed by hypofractionated irradiation.

Criteria

Inclusion Criteria:

  • Ductal carcinoma in situ (DCIS) or invasive ductal, medullary, papillary, colloid (mucinous) lobular or tubular histologies.
  • American Joint Committee on Cancer (AJCC) DCIS or Stage T1- T2, N0 histologically confirmed invasive carcinoma of the breast treated with partial mastectomy with axillary evaluation as appropriate, axillary node dissection or sentinel node biopsy (SLN). Patients with DCIS with or without SLN or axillary node dissection are eligible. Patients greater than 70 years old, with stage 1 disease who are estrogen/progesterone receptor positive (ER/PR+), with or without SLN or axillary node dissection are also eligible.
  • Partial mastectomy with or without reconstruction consisting of local tissue rearrangement and/or reduction mammoplasty (ipsilateral and bilateral). Patients who have undergone surgery and/or chemotherapy prior to treatment with radiation therapy are still eligible for enrollment and all evaluations and photographs will begin prior to radiation. Retrospective Placement of at least 3 surgical clips in the lumpectomy cavity is strongly encouraged. Retrospective data may be collected on women who have completed their entire course of treatment as long as they are formally consented.
  • Unifocal breast cancer which may be encompassed by excision of a single portion of breast tissue.
  • Negative inked histologic margins of partial mastectomy or re-excision specimen to be confirmed prior to radiation. Positive margins are unacceptable. Every effort should be made by the surgeon to obtain negative margins with the initial excision.
  • Negative post-partial mastectomy mammography (if malignancy associated micro-calcifications were initially present.)
  • Tamoxifen or Arimidex therapy is allowed. If chemotherapy is administered prior to radiation (but following surgery), then a minimum of two weeks must elapse prior to the start of radiation therapy.
  • The patient must be 50 years of age or older.
  • Signed study-specific informed consent form prior to study entry.

Exclusion Criteria:

  • Patients enrolled on another clinical trial involving any treatment which may affect the cosmesis of the bilateral breasts. This would include the taking of medications, vitamin supplements, variation in radiation or surgery or topical application to the breast.
  • Patients who are node positive.
  • Patients with distant metastases.
  • Palpable or radiographically suspicious contralateral axillary, supraclavicular, infraclavicular or internal mammary nodes, unless there is histologic confirmation that these nodes are negative for tumor.
  • Any previously treated contralateral breast carcinoma or synchronous ipsilateral breast carcinoma.
  • Prior non-hormonal therapy or radiation therapy for the current breast cancer; prior chemotherapy if administered less than two weeks from the start of therapy.
  • Patients with Paget's disease of the nipple.
  • Patients with prior breast reconstructive surgery including breast mastopexy or breast augmentation.
  • Patients with skin involvement, regardless of tumor size.
  • Patients with collagenous diseases, specifically systemic lupus erythematosis, scleroderma or dermatomyositis.
  • Patients with severe peripheral vascular disease or coronary artery disease (ex. Previous acute myocardial infarction requiring stents or coronary artery bypass graft within past two years; prior bypass graft of any type etc.)
  • Patients with co-existing medical conditions with life expectancy less than 5 years.
  • Patients with psychiatric disorders that would preclude obtaining informed consent.
  • Other malignancy except non-melanomatous skin cancer less than 5 years prior to participation in this study; the disease free interval from any prior carcinoma must be continuous.
  • Patients who are pregnant or lactating.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01400399

Contacts
Contact: Stephanie Shea, RN, OCN 910-343-2862 stephanie.shea@nhrmc.org
Contact: Lynette Racco, RN, BSN, OCN 910-343-4075 lynette.racco@nhrmc.org

Locations
United States, North Carolina
South Atlantic Radiation Oncology Active, not recruiting
Supply, North Carolina, United States, 28462
Coastal Carolina Radiation Oncology Recruiting
Wilmington, North Carolina, United States, 28401
Zimmer Cancer Center Recruiting
Wilmington, North Carolina, United States, 28401
Sponsors and Collaborators
New Hanover Regional Medical Center
Coastal Carolina Radiation Oncology (CCRO)
Investigators
Principal Investigator: Michael Nichols, MD, PhD Coastal Carolina Radiation Oncology
  More Information

No publications provided

Responsible Party: Michael A. Nichols, MD, PhD, Coastal Carolina Radiation Oncology
ClinicalTrials.gov Identifier: NCT01400399     History of Changes
Other Study ID Numbers: ZCC-2010, U54CA142152-02
Study First Received: July 20, 2011
Last Updated: August 10, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by New Hanover Regional Medical Center:
AJCC DCIS or T1- T2, N0

Additional relevant MeSH terms:
Breast Neoplasms
Carcinoma
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on August 26, 2014