Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease (CRESCENT)

This study is currently recruiting participants.
Verified July 2011 by Erasmus Medical Center
Information provided by:
Erasmus Medical Center Identifier:
First received: June 27, 2011
Last updated: July 12, 2011
Last verified: July 2011

Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.

Condition Intervention
Angina Pectoris
Chest Pain
Other: Cardiac CT
Other: Standard care

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease

Resource links provided by NLM:

Further study details as provided by Erasmus Medical Center:

Primary Outcome Measures:
  • Chest pain [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Reduction of chest pain symptoms by standardized questionnaire, at one year follow-up

  • Class IA Revascularizations [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Number of revascularizations with an ESC class 1A indication

Secondary Outcome Measures:
  • Overall medical expenses [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Overall medical expenses

  • Cost-effectiveness [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Cost-effectiveness analysis based on the overall quality of life and medical expenses at one year.

  • Radiation dose [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
    Cumulative radiation exposure at one year

  • Major adverse cardiovascular events [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]

    Composite endpoint of adverse cardiovascular events, including:

    All-cause mortality Non-fatal myocardial infarction Unstable angina requiring hospital admission Late revascularization procedures (>6 months after initial evaluation)

  • Quality of life [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Change of quality of life at 1 year

Estimated Enrollment: 1350
Study Start Date: July 2011
Estimated Study Completion Date: January 2016
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cardiac CT
Cardiac CT (CT calcium and/or CT angiography), followed by stress testing, invasive angiography or neither depending on the CT scan result
Other: Cardiac CT
Cardiac CT: calcium scan and CT coronary angiography
Standard care
Standard diagnostic management, including stress testing and/or invasive angiography
Other: Standard care
Standard care according to international guidelines


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Men and women aged >18 years.
  • Stable symptoms of chest pain or dyspnea potentially caused by obstructive CAD.

Exclusion Criteria:

  • A history of surgical or percutaneous coronary revascularization
  • Non-revascularized angiographic obstructive coronary artery disease (>50% diameter reduction).
  • Normal invasive coronary angiography or stress imaging less than 1 years ago.
  • Inability or unwillingness to provide informed consent.
  Contacts and Locations
Please refer to this study by its identifier: NCT01393028

Contact: Koen Nieman, MD, PhD +31 10 6 3333 4340
Contact: Tjebbe W Galema, MD, PhD +31 10 6 8126 8378

MC Haaglanden Not yet recruiting
Leidschendam, Netherlands
Contact: Joop Schreur, MD   
Erasmus MC Recruiting
Rotterdam, Netherlands
Contact: Koen Nieman, MD, PhD    +31 6 3333 4340   
Contact: Tjebbe Galema, MD, PhD    +31 6 8126 8378   
Havenziekenhuis Not yet recruiting
Rotterdam, Netherlands
Contact: Boudewijn J Krenning, MD, PhD   
Maasstadziekenhuis Not yet recruiting
Rotterdam, Netherlands
Contact: Tobias Bruning, MD, PhD   
Sponsors and Collaborators
Erasmus Medical Center
  More Information

No publications provided

Responsible Party: Koen Nieman, Erasmus MC Identifier: NCT01393028     History of Changes
Other Study ID Numbers: CRESCENT-11
Study First Received: June 27, 2011
Last Updated: July 12, 2011
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Erasmus Medical Center:
coronary artery disease
angina pectoris
Stable chest pain complaints

Additional relevant MeSH terms:
Angina Pectoris
Chest Pain
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms
Arterial Occlusive Diseases processed this record on April 16, 2014