Comparison the Value of Several Biomarkers of Sepsis
The purpose of this study is to describe the value of serum sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score during sepsis and their clinical informative value in predicting outcome.
Systemic Inflammatory Response Syndrome
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Comparison of the Value of Serum sTREM-1, sCD163, PCT, CRP Concentrations, WBC Count and SOFA Score During Sepsis and Their Clinical Informative Value in Predicting Outcome|
- Patients Outcome [ Time Frame: 28 days ] [ Designated as safety issue: No ]The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death
|Study Start Date:||September 2009|
|Study Completion Date:||July 2011|
|Primary Completion Date:||July 2011 (Final data collection date for primary outcome measure)|
(1) temperature > 38oC or < 36oC; (2) pulse rate > 90 beats/min; (3) ventilation rate > 20 breaths/min or hyperventilation with a partial pressure of arterial carbon dioxide (PaCO2) < 32 mmHg; (4) white blood cell (WBC) count >1 2,000μL-1 or < 4000 μL-1 , or > 10% immature cells.
SIRS + infection
The investigators enrolled 130 subjects admitted to an ICU: 30 cases with systemic inflammatory response syndrome (SIRS), 36 cases with sepsis, 35 cases with and 29 with septic shock. Results for sTREM (soluble triggering receptor expressed on myeloid cells)-1, sCD163, procalcitonin (PCT), C-reactive protein (CRP) concentrations, white blood cell (WBC) count and SOFA score were recorded on days 1, 3, 5, 7, 10, and 14.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01388725
|Chinese PLA General Hospital|
|Beijing, Beijing, China, 100853|
|Study Director:||Xie Lixin, Doctor||Department Of Respiratory Diseases, Chinese PLA General Hospital|