Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults
We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation. We then propose to treat the periodontitis and re-evaluate vascular function. We will determine if gingivitis or mild/moderate periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics will be correlated with vascular function.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Oral Flora, Periodontitis, and Vascular Dysfunction in Young Native Americans.|
- Determination of bacterial populations in periodontal samples before and after standard periodontal treatment, stratified by severity of gum disease, using microbial metagenomics analysis. [ Time Frame: Time of enrollment and at 6 week follow up visit ] [ Designated as safety issue: No ]The study will assess if periodontal bacterial flora differ in patients with healthy gums, mild, or severe periodontal disease.
Biospecimen Retention: Samples With DNA
Serum, dental scrapings and saliva
|Study Start Date:||December 2010|
|Study Completion Date:||December 2012|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
|United States, California|
|Indian Health Council|
|Valley Center, California, United States, 92082|
|Principal Investigator:||Roberta A Gottlieb, MD||San Diego State University|