The Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke (COIG)
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Purpose
Previous research has shown there wasn't inevitable relationship between mismatch area and infarct growth according to Volumetric-subtraction mismatch volume.The recently published on Stroke paper has proposed Coregistration mismatch to calculate the mismatch to replace ischaemic penumbra, and it reignites hope for clinical application of the PWI/DWI mismatch. But the correlation between the mismatch, calculated by Coregistration mismatch method,and the clinical outcome of the patients with acute ischemic stroke is still unknown. so the investigators plan to conduct a prospective observational cohort study.
| Condition |
|---|
|
Ischemic Stroke |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | A MRI-based Study of Ischaemic Penumbra: the Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke |
| Estimated Enrollment: | 80 |
| Study Start Date: | August 2011 |
| Estimated Study Completion Date: | August 2013 |
| Estimated Primary Completion Date: | March 2012 (Final data collection date for primary outcome measure) |
NIHSS,mRS and MR PWI/DWI/MRA are performed within 48 hours of stroke onset and final MR T2/flair image at ≈1 month. And then,Volumetric-subtraction mismatch and Coregistered mismatch will be calculated,respectively.finally,we will assess and compare the Volumetric-subtraction mismatch and Coregistered mismatch, and to clarify which method match the clinical outcome more better.
Eligibility| Ages Eligible for Study: | 18 Years to 85 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Patients with acute ischaemic stroke admitted to ASU.
Inclusion Criteria:
- Aged eighteen or above
- Acute middle cerebral artery ischemic stroke
- Stroke onset within 48 hours
- Included a complete set of initial MR images and final outcome MR images up to 1 months
Exclusion Criteria:
- History of stroke in the past 6 weeks
- Pre-existing neurological or psychiatric disease that could confound the study results such as a pre-stroke mRS score greater than 3
- CT evidence of the following conditions before enrollment:
Significant mass effect with midline shift Evidence of intracranial hemorrhage
- With contraindication to MR such as severe allergy to contrast media
Contacts and Locations| China, Beijing | |
| Jianghai Ruan | Not yet recruiting |
| Beijing, Beijing, China, 100078 | |
| Contact: Ruan jiang hai, MD 86-010-64289776 ruanjianghai@126.com | |
More Information
No publications provided
| Responsible Party: | Jianghai Ruan, Dept.of Neurology，Beijing Dongfang Hospital, Beijing University of Chinese Traditional Medicine,Beijing,China |
| ClinicalTrials.gov Identifier: | NCT01376609 History of Changes |
| Other Study ID Numbers: | BUCM-002H-ND |
| Study First Received: | June 17, 2011 |
| Last Updated: | July 29, 2011 |
| Health Authority: | China: National Natural Science Foundation China: State Administration of Traditional Chinese Medicine of the People's Republic of China |
Keywords provided by Beijing Hospital of Traditional Chinese Medicine:
|
Stroke Ischaemic Stroke Cerebral Infarction Cerebrovascular Disorders Brain Diseases Nervous System Diseases Vascular Diseases |
Brain Infarction Brain Ischemia mismatch PWI/DWI mismatch ischaemic penumbra image analysis |
Additional relevant MeSH terms:
|
Infarction Ischemia Stroke Cerebral Infarction Pathologic Processes Necrosis Cerebrovascular Disorders |
Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Brain Ischemia |
ClinicalTrials.gov processed this record on May 16, 2013