Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency (dARICUPEEP)
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure|
- Change from Baseline cerebrovascular autoregulation due to elevated positive end-expiratory pressure [ Time Frame: 1 Year ] [ Designated as safety issue: No ]Is there an impairment of cerebrovascular autoregulation due to positive end-expiratory pressure ventilation this will be a major side effect especial in patients with brain injury.
|Study Start Date:||January 2011|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
patients with respiratory failure and need of high positive end-expiratory pressure ventilation.
Procedure: positive end-expiratory pressure
Elevation of positive end-expiratory failure for recruitment
Other Name: PEEP
Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
|University medical centre|
|Mainz, Germany, 55131|
|Principal Investigator:||Patrick Schramm, MD||Department of Anesthesiology, University medicine Mainz, Germany|