Brain Areas Involved in Sound and Spoken Word Memory
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Purpose
Background:
- Studies have shown that animals such as monkeys and dogs have excellent sight and touch memory but perform poorly on sound memory tasks. Human brains have certain areas that are important for speaking and understanding language. These areas may be involved in sound and spoken word memory. Researchers want to study these areas of the brain to find out if the memory for sounds requires brain structures that are usually associated with language learning and are unique to humans.
Objectives:
- To use magnetic resonance imaging to study areas of the brain involved in sound memory.
Eligibility:
- Healthy right-handed volunteers between 18 and 50 years of age. They must be native English speakers and have completed high school.
Design:
- The study requires a screening visit and 1 or 2 study visits to the National Institutes of Health Clinical Center.
- At the screening visit, volunteers will have a medical history taken. They will also have physical and neurological exams, and complete a questionnaire. Women of childbearing age will give a urine sample. Participants who have not had a magnetic resonance imaging (MRI) scan in the past year will have one at this visit.
- At the second visit, participants will have tests of sound memory. They will listen to a set of nonsense words spoken through earphones and memorize the words. Then they will listen to the words again to judge if the words were part of the earlier list. Participants will have a 1 hour break, then do the sound memory test again. During the second test they will have repetitive transcranial magnetic stimulation (rTMS), which stimulates different regions of the brain.
- If the group results from the testing sessions are positive, there will be a third visit. At this visit, participants will have a sound perception test. They will listen to words spoken through earphones and judge whether the words in the pair are the same or different. Participants will have rTMS during these tests as well.
| Condition |
|---|
|
Brain Mapping Language Disorder Adult Healthy Memory Disorder |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | The Role of the Inferior Frontal Gyrus in Long-Term Auditory Memory - a rTMS Study |
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
- INCLUSION CRITERIA:
To be eligible for this research study participants must:
Be between the ages of 18 and 50 years of age
Be free of any neurologic condition that might affect performance of the tasks in these experiments
Be right handed
Be native English speakers
Have a finished high-school education or equivalent, such as GED
EXCLUSION CRITERIA:
Participants will be excluded from this research study if they:
Are taking medications that include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
Have a diagnosed neurologic or psychiatric condition
Have a history of seizure disorder
Have implanted devices such as pacemakers, medication pumps, or defibrillators, metal in the cranium except the mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may contraindicate or preclude the acquisition of MRI
Have severe back pain or any other condition which might prevent them from lying flat for up to 1 hour
Have Claustrophobia (a fear of tight spaces), which prevents them from lying still in a tight or small space for up to 1 hour
Are currently pregnant
Have known hearing loss
Have an alcohol or substance abuse problem as determined by the screening we will do
Contacts and Locations| Contact: Elaine P Considine, R.N. | (301) 435-8518 | considinee@ninds.nih.gov |
| Contact: Mark Hallett, M.D. | (301) 496-9526 | hallettm@ninds.nih.gov |
| United States, Maryland | |
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
| Bethesda, Maryland, United States, 20892 | |
| Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 prpl@mail.cc.nih.gov | |
| Principal Investigator: | Mark Hallett, M.D. | National Institute of Neurological Disorders and Stroke (NINDS) |
More Information
Additional Information:
Publications:
| ClinicalTrials.gov Identifier: | NCT01375595 History of Changes |
| Other Study ID Numbers: | 110182, 11-N-0182 |
| Study First Received: | June 16, 2011 |
| Last Updated: | March 14, 2013 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
Working Memory Repetitive TMS (rTMS) Language Healthy Volunteer HV |
Additional relevant MeSH terms:
|
Language Disorders Memory Disorders Communication Disorders Neurobehavioral Manifestations |
Neurologic Manifestations Nervous System Diseases Signs and Symptoms |
ClinicalTrials.gov processed this record on May 16, 2013