Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high concentrations of pollutants and, therefore, potentially several risks to health hazards.
Objectives: Assessing cardiopulmonary impacts and inflammatory markers in sugarcane workers and volunteers from a nearby town in non-harvest and harvest periods.
Heart Rate Variability
Systemic Inflammatory Response
|Study Design:||Observational Model: Ecologic or Community
Time Perspective: Prospective
|Official Title:||Effects of Exposure to Outdoor Air Pollution From Biomass Burning on Lung Function, Heart Rate Variability and Systemic Inflammatory Blood Markers in Sugarcane Workers|
- Lung function [ Time Frame: six months ] [ Designated as safety issue: No ]Measurements of lung function in pre harvest and during harvest period
- Heart rate variability [ Time Frame: six months ] [ Designated as safety issue: No ]To evaluate parameters of heart rate variability in pre harvest and during harvest periods
- Oxidative stress [ Time Frame: six months ] [ Designated as safety issue: No ]Measurement of blood levels of antioxidant enzymes and malonaldehyde
- Environmental evaluation [ Time Frame: one year ] [ Designated as safety issue: No ]Measurement of athmospheric concentration of particulate matter.
Biospecimen Retention: Samples With DNA
|Study Start Date:||December 2008|
|Study Completion Date:||February 2011|
|Primary Completion Date:||October 2010 (Final data collection date for primary outcome measure)|
Healthy male volunteers, non-smokers, 20-40yo, living in the city of Mendonça, São Paulo-Brazil.
Healthy male volunteers, non-smokers, 20-40yo, sugarcane workers, living in the city of Mendonça, São Paulo-Brazil.