Trial record 1 of 23 for:
vivo molecular AND cancer AND imaging
Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7-Ag
This study has been completed.
Information provided by (Responsible Party):
Yanqing Li, Shandong University
First received: June 2, 2011
Last updated: December 27, 2011
Last verified: December 2011
The study aims to:
- Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy.
- Compare the results of in vivo MG7-specific molecular imaging with CLE and ex vivo immunohistochemistry .
||Time Perspective: Prospective
||Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7 Antigen
Biospecimen Retention: Samples With DNA
Taken biopsies during endoscopy
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||July 2011 (Final data collection date for primary outcome measure)
Gastric cancer remains the world's second leading cause of cancer-related death. Improved prognosis essentially depend on earlier diagnosis. Gastric monoclonal antibody MG7 has been validated as a specific antibody in gastric cancerous tissue. Conventional evaluation of MG7 antigen expression is immunohistochemistry, which is time-consuming, and the immunoreactivity can be affected by storage and fixation of tissue. Confocal laser endomicrosopy enables visualization of the cellular and subcellular structures in vivo. Thus this study aims to achieve molecular imaging of MG7 antigen in gastric cancer in vivo using confocal laser endomicroscopy.
|Ages Eligible for Study:
||18 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
patients with endoscopically diagnosed gastric cancer
- patients with endoscopically diagnosed gastric cancer
- Patients who are allergic to fluorescein sodium
- Patients who are unwilling to sign or give the informed consent form
- Patients with giant tumors or obvious GI tract bleeding which make it hard or impossible to observe the lesions
- Patients with impaired cardiac, liver or renal function
- Patients with coagulopathy
- Patients with pregnancy or breastfeeding
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01366586
|Department of Gastroenterology, Qilu Hospital, Shandong University
|Jinan, Shandong, China, 250012 |
||Yanqing Li, MD, PhD
||Department of Gastroenterology, Qilu Hospital
No publications provided
||Yanqing Li, Chief of the Department of Gastroenterology, Qilu Hospital, Shandong University, Shandong University
History of Changes
|Other Study ID Numbers:
|Study First Received:
||June 2, 2011
||December 27, 2011
||China: Ministry of Health
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 28, 2014
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases