Inclusion Criteria:

• Patients must have histologically proven neuroblastoma and confirmation of refractory or recurrent disease with histologic confirmation at diagnosis or at the time of recurrence/progression
• Patients must be age > 12 months and ≤ 21 at initial diagnosis.
• Life expectancy must be more than 3 months
• If measurable disease, this must be demonstrated by residual abnormal tissue at a primary or metastatic site measuring more than 1 cm in any dimension by standardized imaging (CT or MRI); tumor must be accessible for biopsy. Patients with bone marrow only disease expected to be > 75% are eligible to enroll.
• Current disease state must be one for which there is currently no known curative therapy
• Lansky or KarnofskyScore must be more than 50
• Patients without bone marrow metastases must have an ANC > 750/μl and platelet count > 50,000/μl

• Adequate liver function must be demonstrated, defined as:

  • Total bilirubin ≤ 1.5 x upper limit of normal (ULN) for age AND
  • SGPT (ALT) < 10 x upper limit of normal (ULN) for age
• No other significant organ toxicity defined as > Grade 2 by National Cancer Institute Common Toxicity Criteria for Adverse Events NCI-CTCAE V4.0
• A negative serum pregnancy test is required for female participants of child bearing potential (≥ 13 years of age or after onset of menses)
• Both male and female post-pubertal study subjects need to agree to use one of the more effective birth control methods during treatment and for six months after treatment is stopped. These methods include total abstinence (no sex), oral contraceptives ("the pill"), an intrauterine device (IUD), levonorgestrol implants (Norplant), or medroxyprogesterone acetate injections (Depo-provera shots). If one of these cannot be used, contraceptive foam with a condom is recommended.
• Informed Consent: All patients and/or legal guardians must sign informed written consent. Assent, when appropriate, will be obtained according to institutional guidelines. Voluntary consent for optional biology studies will be included.

Exclusion Criteria:

• Patients who have received any chemotherapy within the last 7 days prior to enrollment and 14 days prior to study treatment start date.
• Patients who have received any radiotherapy within the last 30 days must have another site of disease to follow.
• Patients receiving anti-tumor therapy for their disease or any investigational drug concurrently
• Patients with serious infection or a life-threatening illness (unrelated to tumor) that is > Grade 2 (NCI CTCAE V4.0), or active, serious infections requiring parenteral antibiotic therapy.
• Patients with any other medical condition, including malabsorption syndromes, mental illness or substance abuse, deemed by the Investigator to be likely to interfere with the interpretation of the results or which would interfere with a patient's ability to sign or the legal guardian's ability to sign the informed consent, and patient's ability to cooperate and participate in the study