Study of the Clinical Scoring System and Cytokines for Prediction of Inflammatory Response in Major Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome. The aim of this study is to assess the effectiveness of clinical scoring systems and inflammatory cytokine levels for predicting systemic inflammation. This correlation might identify peri-operative clinical outcomes, then forecast further systemic inflammation in cardiac and hepatic surgical patients.
Heart; Dysfunction Postoperative, Cardiac Surgery
Cytokine Release Syndrome
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Prediction for Systemic Inflammation With Clinical Scoring Systems and Inflammatory Cytokine Levels in Adult Cardiac and Major Abdominal Surgical Patients|
- Correlation of clinical scoring systems and inflammatory cytokine levels [ Time Frame: 24 h after CPB ] [ Designated as safety issue: No ]Blood samples were collected sequentially at 0, 0.5, 4, 12, and 24 h after CPB for cytokines [Interleukin (IL)-6, IL-8, and IL-10] investigation and leukocyte counts. Clinical scoring systems [Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA) and Multi-Organ Dysfunction (MOD)] were calculated and recorded at each time point. Correlations were assessed.
Biospecimen Retention: Samples Without DNA
whole blood taken from arterial line
|Study Start Date:||March 2010|
|Study Completion Date:||December 2010|
|Primary Completion Date:||October 2010 (Final data collection date for primary outcome measure)|
|patients with elective cardiac surgery|
Systemic inflammatory response syndrome (SIRS) is commonly found in most major surgery. Early detection of SIRS will lead to early treatment. Serum cytokines levels are reliable markers for SIRS detection but with high cost and inconvenience. Clinical Scoring Systems are commonly used for assessment of patients with SIRS. If they have good correlation with cytokine levels, they might be used to predict peri-operative clinical outcomes.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01353157
|Queen Sirikit Heart Center of the Northeast, Khon Kaen University|
|Khon Kaen, Thailand, 40002|
|Principal Investigator:||Sirirat Tribuddharat, MD||Faculty of Medicine, Khon Kaen University|