Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2011 by Universitaire Ziekenhuizen Leuven.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Universitaire Ziekenhuizen Leuven
ClinicalTrials.gov Identifier:
NCT01352923
First received: May 11, 2011
Last updated: NA
Last verified: May 2011
History: No changes posted
  Purpose

In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.


Condition Intervention
Platelet Function
Other: blood test

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

Further study details as provided by Universitaire Ziekenhuizen Leuven:

Estimated Enrollment: 100
Study Start Date: May 2011
Estimated Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: peripheral blood
healthy voluntary donors
Other: blood test
preparation of blood platelets

Detailed Description:

Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors. Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists. Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability. PEAR1 is mainly expressed in platelets and endothelial cells. A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists. However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy voluntary donors

Exclusion Criteria:

  • none
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01352923

Contacts
Contact: Alexandre Kauskot alexandre.kauskot@med.kuleuven.be
Contact: Peter Verhamme Peter.Verhamme@uzleuven.be

Locations
Belgium
KUleuven/UZ Gasthuisberg Recruiting
Leuven, Vlaams Brabant, Belgium, 3000
Contact: Alexandre Kauskot    +3216346145      
Contact: Marc Houlaerts    +3216346145      
Principal Investigator: Marc Hoylaerts         
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Investigators
Principal Investigator: Marc Hoylaerts Katholieke Universiteit Leuven
  More Information

No publications provided

Responsible Party: Prof. Marc Hoylaerts, KULeuven
ClinicalTrials.gov Identifier: NCT01352923     History of Changes
Other Study ID Numbers: B322201111373
Study First Received: May 11, 2011
Last Updated: May 11, 2011
Health Authority: Belgium: Federal Agency for Medicinal Products and Health Products

Keywords provided by Universitaire Ziekenhuizen Leuven:
PEAR1 gene
whether and how PEAR 1 modulate intracellular signaling pathways relevant for platelet function

ClinicalTrials.gov processed this record on July 28, 2014