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a 3.0T Magnetic Resonance Imaging Study

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2011 by Huazhong University of Science and Technology.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Sun Yat-sen University
Information provided by:
Huazhong University of Science and Technology
ClinicalTrials.gov Identifier:
NCT01346904
First received: May 2, 2011
Last updated: NA
Last verified: May 2011
History: No changes posted
  Purpose

Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.


Condition
Primary Open Angle Glaucoma

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Central Nerve System Injury in Patients With Primary Open Angle Glaucoma

Resource links provided by NLM:

MedlinePlus related topics: Glaucoma MRI Scans
U.S. FDA Resources

Further study details as provided by Huazhong University of Science and Technology:

Estimated Enrollment: 200
Study Start Date: May 2011
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

All subjects recruited from the Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Clinical ophthalmic assessments including measurement of visual acuities, intraocular pressure, slit-lamp microscopes and funduscopes examinations, cup-to-dick ratio (CDR) evaluation, visual field test [Octopus 101 Automated Perimeter, Haag-streit, Switzerland. Program G2], optical coherence tomography for retinal nerve fiber layer thickness(RNFLT) around the optic disk[Stratus OCT，Carl Zeiss Meditec, Dublin, CA .Scan Type :Fast RNFLT 3.4, Scan Length: 10.87mm].

Criteria

Inclusion Criteria:

  • Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
  • matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion Criteria:

  • optic neuropathy
  • neurological disorder
  • other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01346904

Sponsors and Collaborators
Huazhong University of Science and Technology
Sun Yat-sen University
Investigators
Study Chair: HONG ZHANG, PHD Tongji Hospital
  More Information

No publications provided

Responsible Party: HONG ZHANG, Department of Opthalmology ,Tongji Hospital
ClinicalTrials.gov Identifier: NCT01346904     History of Changes
Other Study ID Numbers: POAG3243
Study First Received: May 2, 2011
Last Updated: May 2, 2011
Health Authority: China: Ministry of Health

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on June 17, 2013