The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes (HITPET)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2011 by Turku University Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
European Foundation for the Study of Diabetes
Ministry of Culture and Education
Orion Farmos Research Foundation
Academy of Finland
Turku PET Centre
University of Turku
Verve Research, Oulu
Helsinki University
Information provided by:
Turku University Hospital
ClinicalTrials.gov Identifier:
NCT01344928
First received: April 28, 2011
Last updated: NA
Last verified: April 2011
History: No changes posted
  Purpose

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).


Condition Intervention
Type 2 Diabetes Mellitus
Healthy Volunteers
Behavioral: HIT exercise intervention
Behavioral: Aerobic exercise intervention

Study Type: Interventional

Resource links provided by NLM:


Further study details as provided by Turku University Hospital:

Arms Assigned Interventions
Experimental: HIT training Behavioral: HIT exercise intervention
Active Comparator: Aerobic exercise training Behavioral: Aerobic exercise intervention

  Eligibility

Ages Eligible for Study:   40 Years to 55 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

The healthy patients

  1. Age 40-55
  2. BMI 18.5-30
  3. Fasting plasma glucose less than 6.1 mmol/l
  4. Normal glucose tolerance test (OGTT)

The type 2 diabetic patients:

  1. Age-, sex-, and BMI-matched with the study subjects in the phase 1
  2. In a good treatment balance
  3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
  4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

Exclusion Criteria:

The healthy patients

  1. Blood pressure > 140/90 mmHg
  2. Any chronic disease
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Previous use of anabolic steroids, additives or any other substrates
  7. Smoking of tobacco, taking of snuffs, or use of narcotics.
  8. Significant use of alcohol
  9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  10. Presence of any ferromagnetic objects that would make MR imaging contraindicated
  11. Current or history of regular and systematic exercise training
  12. VO2max >40 ml/min/kg

The type 2 diabetic patients:

  1. Any other chronic disease than diabetes
  2. Blood pressure > 140/90 mmHg
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Smoking of tobacco, taking of snuffs, or use of narcotics.
  7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated
  9. Current or history of regular and systematic exercise training
  10. VO2max >40 ml/ min/kg
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01344928

Locations
Finland
Turku PET Centre Recruiting
Turku, Finland, 20521
Contact: Jarna C Hannukainen, PhD    +358-2-3131878    jarna.hannukainen@tyks.fi   
Principal Investigator: Jarna C Hannukainen, PhD         
Sub-Investigator: Kari K Kalliokoski, PhD         
Sub-Investigator: Joonas J Eskelinen, BM         
Sub-Investigator: Anna Savolainen, BM         
Sub-Investigator: Ilkka Heinonen, PhD         
Sub-Investigator: Kirsi A Virtanen, PhD         
Sub-Investigator: Jukka Kemppainen, PhD         
Sub-Investigator: Juhani Knuuti, Professor         
Sub-Investigator: Pirjo Nuutila, Professor         
Sub-Investigator: Jussi Pärkkä, MD         
Sub-Investigator: Virva Lepomäki, MSc         
Sub-Investigator: Riitta Parkkola, MD, PhD         
Sponsors and Collaborators
Turku University Hospital
European Foundation for the Study of Diabetes
Ministry of Culture and Education
Orion Farmos Research Foundation
Academy of Finland
Turku PET Centre
University of Turku
Verve Research, Oulu
Helsinki University
  More Information

No publications provided

Responsible Party: Jarna Hannukainen, Turku PET Centre
ClinicalTrials.gov Identifier: NCT01344928     History of Changes
Other Study ID Numbers: 95/180/2010
Study First Received: April 28, 2011
Last Updated: April 28, 2011
Health Authority: Finland: Ethical committee of the Hospital District of the South-Western Finland

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on August 27, 2014