The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Zhongheng Zhang, Jinhua Central Hospital
ClinicalTrials.gov Identifier:
NCT01344265
First received: April 27, 2011
Last updated: April 1, 2013
Last verified: September 2012
  Purpose

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.


Condition
Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Correlation Between BNP and Global End Diastolic Volume

Further study details as provided by Jinhua Central Hospital:

Primary Outcome Measures:
  • global end diastolic volume [ Time Frame: within 12 h after measurement of BNP ] [ Designated as safety issue: Yes ]
    this is measured by transpulmonary thermodilution technique


Enrollment: 46
Study Start Date: June 2010
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
consecutive patients
there is only one group in our study

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

critically ill patients who required hemodynamic monitoring using PiCCO

Criteria

Inclusion Criteria:

  • critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

  • patients with renal dysfunction
  • those older than 80 years
  • pregnant women
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01344265

Locations
China, Zhejiang
Jinhua central hospital
Jinhua, Zhejiang, China, 321000
Sponsors and Collaborators
Jinhua Central Hospital
Investigators
Study Chair: Zhongheng Zhang, MD Jinhua Central Hospital
  More Information

No publications provided

Responsible Party: Zhongheng Zhang, Dr., Jinhua Central Hospital
ClinicalTrials.gov Identifier: NCT01344265     History of Changes
Other Study ID Numbers: zh_zhang1984
Study First Received: April 27, 2011
Last Updated: April 1, 2013
Health Authority: China: SFDA

Keywords provided by Jinhua Central Hospital:
B-type natriuretic peptide
global end diastolic volume

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs
Pharmacologic Actions
Cardiovascular Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on October 01, 2014