Text Size

Study of Toddlers With Language Delay

This study is currently recruiting participants.
Verified November 2012 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT01339767
First received: April 20, 2011
Last updated: May 1, 2013
Last verified: November 2012
History of Changes
  Purpose

The purpose of this study is to learn more about risk factors for autism by studying the behavior and brain functioning of toddlers with early communication delays and typically developing toddlers. Children 12 or 18 months of age with language delays (i.e., no words at 18 months, limited vocalizations at 12 months) and typically developing toddlers may be eligible to participate. This study will be conducted at the NIH Clinical Center in Bethesda, Maryland. There will be an initial screening evaluation that will include behavioral assessment. Eligible participants will then complete a baseline visit that includes an overnight sleep study that includes Electroencephalogram (EEG) test to measure brain electrical activity, and an MRI scan. Follow-up visits that include behavioral assessment will occur every 6-12 months, depending on age at study entry. The final study visit will occur at 36 months of age and will include behavioral assessment, sleep/EEG study, and MRI. There is no cost for participation. Compensation will be provided. To find out if your child qualifies or for more information, please call 301-451-7822 (TTY: 1-866-411-1010) or e-mail NIMH-ASD@mail.nih.gov. National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services....


Condition
Autism
Language Acquisition
Language Development
Toddlers

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Markers of Autism Spectrum Disorders in At-Risk Toddlers: A Pilot Study

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 149
Study Start Date: April 2011
Detailed Description:

Objective

This investigation will focus on two areas: 1) early communication impairments as predictors of autism spectrum disorder (ASD) and later developmental delays, and 2) the relationship between communication and evidence of CNS function (sleep, EEG) and structure (MRI - DTI and volumetrics) in young children at risk for ASD. The objective is to delineate early communicative impairments that predict ASD vs. other developmental delays and to examine how these impairments correlate with brain abnormalities in both structure and function.

Study Population

We will recruit 64 children [n=32 at 12 months of age (plus or minus 2 months); n=32 at 18 months of age (plus or minus 2 months)] who are at-risk for ASD due to communication/language delays (at-risk group). The at-risk children will be matched at initial on chronological age, SES, and sex, to typically developing children (n=75) with no history of developmental delays. These 139 participants will hereafter be referred to as the toddler sample. At the 36 month final visit, diagnostic status (e.g. ASD, non-ASD specific delays, catch up) will be determined for children in the at-risk group. In addition, 10 healthy adults, aged 18-40 will serve as control participants for the purpose of piloting the functional paradigms for the MRI portion of the protocol.

Design

We propose to conduct a prospective, longitudinal study of toddlers at-risk for ASD compared to typically developing toddlers. Children will complete behavioral testing and an overnight Sleep/EEG as well as MRI at either a 12 or 18 month initial. Follow-up visits that include behavioral assessment will occur at 24 and 36 months for all children (and at 18 months of age for the 12-month cohort). The Sleep/EEG and MRI will be repeated at the 36 month final follow-up.

Outcome Measures

Autism symptoms, language status, and cognitive development at 36 months will serve as the primary outcome measures.

  Eligibility

Ages Eligible for Study:   10 Months to 20 Months
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

At-risk Group:

  1. 12 or 18 months of age (plus or minus 2 months)
  2. Limited spoken words (for both the 12 and 18 month groups)
  3. Expressive and Receptive scores in the Very Low range on the Mullen Scales of Early Learning (a standardized observational measure),

Typically Developing Group:

  1. 12 or 18 months of age (plus or minor 2 months)
  2. Development in nonverbal and verbal areas within age expectations (per scores on all 4 domains of the Mullen Scales of Early learning no more than 1.5 standard deviation below the mean).

Healthy Adult Group:

1. 18-40 years old

EXCLUSION CRITERIA:

At-risk Group:

  1. Primary language spoken in the home is other than English
  2. Prematurity at birth (defined as less than 36 weeks gestation), or birth weight significantly below normal for gestational age (SGA- small for gestational age) or other significant birth trauma.
  3. Motor or other medical impairment deemed responsible for delays (e.g. cerebral palsy; known genetic disorder)

Typically Developing Group:

  1. Primary language spoken in the home is other than English
  2. Prematurity at birth (defined as less than 36 weeks gestation); or birth weight significantly below normal for gestational age (SGA- small for gestational age).
  3. Motor or other medical impairment that would interfere with study participation
  4. Known genetic disorder
  5. Status as a younger sibling of a child diagnosed with autism

Healthy Adult Group:

  1. Historical or current psychiatric, neurological, or serious medical illness
  2. Primary language is other than English
  3. Difficulty hearing (as some sounds and words will be presented during the MRI scan)
  4. Head injury with loss of consciousness in the last year
  5. Metal in the body which would make having an MRI scan unsafe, such as pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent eye liner or small metal fragments in the eye that welders and other metal workers may have.
  6. Discomfort in small closed spaces (have claustrophobia) so that there would be discomfort in the MRI machine.
  7. Inability to lie comfortably flat on the back for up to 60 minutes in the MRI scanner
  8. If female, and pregnant
  9. Inability to provide own consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01339767

Contacts
Contact: Audrey E Thurm, Ph.D. (301) 496-5323 at191u@nih.gov

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)     800-411-1222 ext TTY8664111010     prpl@mail.cc.nih.gov    
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Audrey E Thurm, Ph.D. National Institute of Mental Health (NIMH)
  More Information

Additional Information:
NIH Clinical Center Detailed Web Page  This link exits the ClinicalTrials.gov site

Publications:

ClinicalTrials.gov Identifier: NCT01339767     History of Changes
Other Study ID Numbers: 110144, 11-M-0144
Study First Received: April 20, 2011
Last Updated: May 1, 2013
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Autism
Language Acquisition
Language Development
Toddlers

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on May 21, 2013