Frequency and Origin of Dysnatremias in the Emergency Department

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by University Hospital Inselspital, Berne.
Recruitment status was  Not yet recruiting
Sponsor:
Collaborator:
Steering committee of the NCCR
Information provided by:
University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier:
NCT01326429
First received: March 29, 2011
Last updated: April 17, 2012
Last verified: April 2012
  Purpose

Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in the prevalence of the electrolyte disorders. Only little data is available on the frequency and the mechanisms leading to hypo-/hypernatremia.

Thus, the investigators aim to A.) determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital and B.) explore the mechanisms leading to the development of dysnatremias by detailed clinical and laboratory examinations.


Condition
Hyponatremia
Hypernatremia

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Frequency and Origin of Dysnatremias in the Emergency Department

Further study details as provided by University Hospital Inselspital, Berne:

Primary Outcome Measures:
  • Frequency of hypo- and hypernatremia in the emergency department [ Time Frame: approx. 6 months ] [ Designated as safety issue: No ]
    We aim to determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital.


Secondary Outcome Measures:
  • Origin of hypo- and hypernatremia in the emergency department [ Time Frame: approx. 6 months ] [ Designated as safety issue: No ]
    We try to investiagte the mechanisms leading to the development of hypo- and hypernatremia in patients admitted to the emergency department.


Biospecimen Retention:   Samples With DNA

whole blood


Estimated Enrollment: 200
Study Start Date: August 2012
Groups/Cohorts
Hypernatremia
Patients admitted to the emergency department with a serum sodium exceeding 145 mmol/L.
Hyponatremia
Patients admitted to the emergency room with a serum sodium below 135 mmol/L.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All patients admitted to the emergency department of a large tertiary university hospital with a serum sodium below 135 mmol/L (hyponatremia) or exceeding 145 mmol/L.

Criteria

Inclusion Criteria:

  • Serum sodium below 135 mmol/L (i.e. hyponatremia); serum sodium exceeding 145 mmol/L (hypernatremia)

Exclusion Criteria:

  • Patients below age 18 years; patients declining study participation.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01326429

Contacts
Contact: Gregor Lindner, M.D. +41326329629 gregor.lindner@insel.ch
Contact: Felix J Frey, M.D. +41316329629 felix.frey@insel.ch

Locations
Switzerland
Inselspital Bern, University of Bern Not yet recruiting
Bern, Switzerland, 3010
Contact: Gregor Lindner, M.D.    +41316329629    gregor.lindner@insel.ch   
Contact: Felix J Frey, M.D.    +41316329629    felix.frey@insel.ch   
Principal Investigator: Gregor Lindner, M.D.         
Sub-Investigator: Daniel Ackermann, M.D.         
Sponsors and Collaborators
University Hospital Inselspital, Berne
Steering committee of the NCCR
Investigators
Principal Investigator: Gregor Lindner, M.D. Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
Study Chair: Felix J Frey, M.D. Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
  More Information

Additional Information:
No publications provided

Responsible Party: Gregor Lindner M.D., Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
ClinicalTrials.gov Identifier: NCT01326429     History of Changes
Other Study ID Numbers: KEK 019/11
Study First Received: March 29, 2011
Last Updated: April 17, 2012
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital Inselspital, Berne:
Sodium
Hyponatremia
Hypernatremia
Emergency department

Additional relevant MeSH terms:
Emergencies
Hypernatremia
Hyponatremia
Disease Attributes
Metabolic Diseases
Pathologic Processes
Water-Electrolyte Imbalance

ClinicalTrials.gov processed this record on October 30, 2014