Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborators:
University of Maryland, Baltimore County
Rensselaer Polytechnic Institute
Johns Hopkins University
Massachusetts General Hospital
University of Delaware
US Department of Housing and Urban Development
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT01323322
First received: March 24, 2011
Last updated: July 23, 2014
Last verified: June 2014
  Purpose

The Healthy Aging in Neighborhoods of Diversity across the Life Span study (HANDLS) is a multidisciplinary, community-based, prospective longitudinal epidemiologic study examining the influences of race and socioeconomic status (SES) on the development of age-related health disparities among socioeconomically diverse African Americans and whites in Baltimore. This study investigates whether health disparities develop or persist due to differences in SES, differences in race, or their interaction. This study is unique because it will assess over a 20-year period physical parameters as well as evaluate genetic, biologic, demographic, and psychosocial parameters of African American and white participants in higher and lower SES. It also employs novel research tools, mobile medical research vehicles, in hopes of improving participation rates and retention among non-traditional research participants. The domains of the HANDLS study include: nutrition, cognition, biologic biomarkers, body composition and bone quality, physical function and performance, sociodemographics, psychosocial, neighborhood environment and cardiovascular disease. Utilizing data from these study domains will facilitate understand the driving factors behind persistent black-white health disparities in overall longevity, cardiovascular disease, and cognitive decline.

HANDLS Wave 1, the initial recruitment and examination phase that began in August 2004, is complete. The current protocol outlines the revisit waves of this study HANDLS Wave, 2 entitled, The Association of Personality and Socioeconomic status with Health Status An Interim Follow-up Study, which began in June 2006 under a separate protocol is designed as a telephone interview to occur approximately 18 months after the first visit to the mobile Medical Research Vehicles (MRVs). Wave 2 provides interim contact with study participants, and important interim information regarding their health. The next visit HANDLS Wave 3 will consist of the second visit to the mobile Medical Research Vehicles (MRVs) for a health examination to occur at least 3 years after the first, a telephone interview to include the dietary interview and questionnaires, and for a random sample of those who participate in the revisit a direct measurement of renal function and a brain scan study using M RI to examine the structure of the brain.


Condition
HTN
Diabetes
Heart Disease
Cancer
Alzheimer's Disease

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 4000
Study Start Date: June 2009
Detailed Description:

The Healthy Aging in Neighborhoods of Diversity across the Life Span study (HANDLS) is a multidisciplinary, community-based, prospective longitudinal epidemiologic study examining the influences of race and socioeconomic status (SES) on the development of age-related health disparities among socioeconomically diverse African Americans and whites in Baltimore. This study investigates whether health disparities develop or persist due to differences in SES, differences in race, or their interaction. This study is unique because it will assess over a 20-year period physical parameters as well as evaluate genetic, biologic, demographic, and psychosocial parameters of African American and white participants in higher and lower SES. It also employs novel research tools, mobile medical research vehicles, in hopes of improving participation rates and retention among non-traditional research participants. The domains of the HANDLS study include: nutrition, cognition, biologic biomarkers, body composition and bone quality, physical function and performance, sociodemographics, psychosocial, neighborhood environment and cardiovascular disease. Utilizing data from these study domains will facilitate understand the driving factors behind persistent black-white health disparities in overall longevity, cardiovascular disease, and cognitive decline.

HANDLS recruited a fixed cohort as an area probability sample of Baltimore City from August 2004 through November 2009 as Wave 1 (Figure 1). HANDLS Wave 2 entitled The Association of Personality and Socioeconomic status with Health Status An Interim Follow-up Study began in June 2006 under a separate protocol. It was designed as a follow-up telephone interview approximately 18 months after the initial examination (Wave 1) was complete. Wave 2 provided interim contact with study participants, and important interim information regarding their health. Now completed, wave 3 was the first follow-up examination and participants second visit to our mobile Medical Research Vehicles (MRVs). The current protocol outlines Wave 4, the second follow-up examination and participants third visit to our mobile Medical Research Vehicles (MRVs). Planned as a follow-up after 3-4 years, Wave 4 consists of health examinations, a telephone dietary-recall interview, renal function assessments, and optional studies of circadian rhythm, structural MRIs, and an evaluation of the subjective experience of diabetes mellitus.

  Eligibility

Ages Eligible for Study:   30 Years to 64 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

Verified HANDLS participants

Able to give informed consent

Must have valid picture identification

EXCLUSION CRITERIA:

Pregnancy

Current cancer chemotherapy or radiation therapy

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01323322

Locations
United States, Maryland
National Institute of Aging, Clinical Research Unit
Baltimore, Maryland, United States, 21224
University of Maryland at Baltimore/MPRC
Catonsville, Maryland, United States, 21228
Sponsors and Collaborators
University of Maryland, Baltimore County
Rensselaer Polytechnic Institute
Johns Hopkins University
Massachusetts General Hospital
University of Delaware
US Department of Housing and Urban Development
Investigators
Principal Investigator: Michele K Evans, M.D. National Institute on Aging (NIA)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT01323322     History of Changes
Other Study ID Numbers: 999909248, 09-AG-N248
Study First Received: March 24, 2011
Last Updated: July 23, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Health Disparities
Diversity
Socioeconomic Status
Epidemiology

Additional relevant MeSH terms:
Alzheimer Disease
Heart Diseases
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Cardiovascular Diseases

ClinicalTrials.gov processed this record on July 26, 2014