Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2012 by University of Tromso
Sponsor:
Collaborator:
The Royal Norwegian Ministry of Health
Information provided by (Responsible Party):
University of Tromso
ClinicalTrials.gov Identifier:
NCT01322984
First received: March 2, 2011
Last updated: October 24, 2012
Last verified: October 2012
  Purpose

Children and youth diagnosed with autism spectrum disorder (ASD) have been shown to react abnormally to social stimuli, especially to human faces. Children and youth with ASD show less interest in social stimuli, and may even avoid looking at or interact with such stimuli. It has been proposed that social stimuli elicit reactions like fear and stress in individuals with ASD, and this explains the lack of interest and avoidance. The present project investigates this hypothesis.


Condition Intervention
Autism Spectrum Disorder
Behavioral: Pictures
Behavioral: Startle eliciting noise

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder

Resource links provided by NLM:


Further study details as provided by University of Tromso:

Primary Outcome Measures:
  • The eyeblink of the Startle reflex is measured. [ Time Frame: The startle reflex will be measured in relation to picture presentations during the experiment (e.g. day 1). ] [ Designated as safety issue: No ]
    The startle reflex is potentiated when participants are influenced by negative emotions. Accordingly, startle will be measured in relation to picture presentation to gauge the emotional effect of the pictures. It is expected that the ASD group will show fear potentiated startle to pictures of human faces.


Estimated Enrollment: 60
Study Start Date: March 2011
Estimated Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Normal controls
Normal children and youths
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.
Experimental: ASD
Children and youths diagnosed with autism spectrum disorder (ASD)
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.

  Eligibility

Ages Eligible for Study:   7 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

For ASD group:

Inclusion Criteria:

  • Diagnosed with autism spectrum disorders
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01322984

Locations
Norway
Department of Psychology, University of Tromso Not yet recruiting
Tromso, Troms, Norway, 9037
Contact: Ole Åsli, PhD    77646778    ole.asli@uit.no   
Principal Investigator: Ole Åsli, PhD         
Sponsors and Collaborators
University of Tromso
The Royal Norwegian Ministry of Health
  More Information

Additional Information:
No publications provided

Responsible Party: University of Tromso
ClinicalTrials.gov Identifier: NCT01322984     History of Changes
Other Study ID Numbers: 2010/238
Study First Received: March 2, 2011
Last Updated: October 24, 2012
Health Authority: Norway: Regional Ethics Commitee

Keywords provided by University of Tromso:
ASD
Startle

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on July 20, 2014