Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder
This study is not yet open for participant recruitment.
Verified October 2012 by University of Tromso
Sponsor:
University of Tromso
Collaborator:
The Royal Norwegian Ministry of Health
Information provided by (Responsible Party):
University of Tromso
ClinicalTrials.gov Identifier:
NCT01322984
First received: March 2, 2011
Last updated: October 24, 2012
Last verified: October 2012
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Purpose
Children and youth diagnosed with autism spectrum disorder (ASD) have been shown to react abnormally to social stimuli, especially to human faces. Children and youth with ASD show less interest in social stimuli, and may even avoid looking at or interact with such stimuli. It has been proposed that social stimuli elicit reactions like fear and stress in individuals with ASD, and this explains the lack of interest and avoidance. The present project investigates this hypothesis.
| Condition | Intervention |
|---|---|
|
Autism Spectrum Disorder |
Behavioral: Pictures Behavioral: Startle eliciting noise |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Cognitive and Emotional Processing of Social Stimuli in Children and Youth With Autism Spectrum Disorder |
Resource links provided by NLM:
Further study details as provided by University of Tromso:
Primary Outcome Measures:
- The eyeblink of the Startle reflex is measured. [ Time Frame: The startle reflex will be measured in relation to picture presentations during the experiment (e.g. day 1). ] [ Designated as safety issue: No ]The startle reflex is potentiated when participants are influenced by negative emotions. Accordingly, startle will be measured in relation to picture presentation to gauge the emotional effect of the pictures. It is expected that the ASD group will show fear potentiated startle to pictures of human faces.
| Estimated Enrollment: | 60 |
| Study Start Date: | March 2011 |
| Estimated Primary Completion Date: | January 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: Normal controls
Normal children and youths
|
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.
|
|
Experimental: ASD
Children and youths diagnosed with autism spectrum disorder (ASD)
|
Behavioral: Pictures
The participants will be exposed to pictures of faces and non-facial stimuli presented on a PC screen.
Behavioral: Startle eliciting noise
Startle will be elicited by 95 dB noise, presented at different times after picture onset.
|
Eligibility| Ages Eligible for Study: | 7 Years to 18 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
For ASD group:
Inclusion Criteria:
- Diagnosed with autism spectrum disorders
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01322984
Locations
| Norway | |
| Department of Psychology, University of Tromso | Not yet recruiting |
| Tromso, Troms, Norway, 9037 | |
| Contact: Ole Åsli, PhD 77646778 ole.asli@uit.no | |
| Principal Investigator: Ole Åsli, PhD | |
Sponsors and Collaborators
University of Tromso
The Royal Norwegian Ministry of Health
More Information
Additional Information:
No publications provided
| Responsible Party: | University of Tromso |
| ClinicalTrials.gov Identifier: | NCT01322984 History of Changes |
| Other Study ID Numbers: | 2010/238 |
| Study First Received: | March 2, 2011 |
| Last Updated: | October 24, 2012 |
| Health Authority: | Norway: Regional Ethics Commitee |
Keywords provided by University of Tromso:
|
ASD Startle |
Additional relevant MeSH terms:
|
Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Diagnosed in Childhood Mental Disorders |
ClinicalTrials.gov processed this record on May 22, 2013