Measurement of Kidney Blood Flow and Oxygen Levels by MRI
The traditional measurement of renal blood flow in ml/min involves the collection of multiple blood and urine samples after an infusion of a drug called para-aminohippurate (PAH) is given. In this study, the investigators determine the ability of MRI to estimate renal blood flow. The primary hypothesis is that renal blood flow as measured by PAH clearance is similar to renal blood flow as estimated by MRI. The measurements by PAH clearance and MRI are both performed on the same day.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||MRI for the Non-invasive Determination of Renal Blood Flow and Renal Oxygenation|
- Comparison of renal blood flow (RBF in ml/min) by PAH infusion versus estimation by MRI [ Time Frame: RBF measured over 1 hour by PAH and 30 minutes by MRI (day 1) ] [ Designated as safety issue: No ]Both measures are obtained on the same day and the results are compared.
- Measurement of regional blood oxygenation by MRI [ Time Frame: One measure before and after furosemide (day 1) ] [ Designated as safety issue: No ]
|Study Start Date:||October 2010|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
Active Comparator: Furosemide
With and without furosemide
Renal blood flow is measured before and after the administration of 20 mg of furosemide.
Other Name: Lasix
Please refer to this study by its ClinicalTrials.gov identifier: NCT01318967
|United States, North Carolina|
|Wake Forest University Health Sciences|
|Winston-Salem, North Carolina, United States, 27157|
|Principal Investigator:||Michael Rocco, MD||Wake Forest School of Medicine|