Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.
The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation|
- Multi-organ failure [ Time Frame: daily for 48 hours then weekly for 2 weeks. ] [ Designated as safety issue: No ]Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.
- Mortality [ Time Frame: ICU mortality ] [ Designated as safety issue: No ]All the patient will be followed up to 28-days to determine survival.
|Study Start Date:||November 2013|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock.
The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.
Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01315782
|Contact: Rosa M Estrada-Y-Martin, MD MScfirstname.lastname@example.org|
|United States, Texas|
|Memorial Hermann Hospital||Recruiting|
|Houston, Texas, United States, 77030|
|Contact: Rosa M Estrada-Y-Martin, MD MSc 713-500-6830 email@example.com|
|Principal Investigator:||Rosa M Estrada-Y-Martin, MD MSc||The University of Texas Health Science Center, Houston|